Prioris (ME) on 09/04/2026

Diosmin is used to fix problems in the lower legs, like blood pooling, pumps related to veins and vein problems in general. It has worked wonders for these problems.

So I have been taking Diosmin for a while for various things. At some point in recent weeks, I stopped taking it. I notice my RLS acting up more.

There may be a connection here. I notice Life Extension has it listed but not here. Just take two or three capsules once a day and see ifit responds.

LIFE EXTENSION

What Natural Interventions May Be Beneficial for Restless Leg Syndrome?

• Iron. Iron deficiency or altered brain iron metabolism have been linked to RLS; supplementation is often recommended for RLS patients who have been tested and shown to be deficient. Iron supplementation has been shown to significantly improve symptoms in iron-deficient RLS patients.
• Folate. Low levels of folate may play a role in RLS, especially in pregnant women. Pregnant women with lower folate levels were more likely to develop RLS than women who took vitamins during pregnancy.
• Magnesium. Low magnesium levels can cause excitability of neurons; magnesium supplements are often used to prevent abnormal activity in the nervous system. A case study indicated magnesium may improve symptoms and sleep problems associated with RLS.
• Diosmin. Diosmin is a natural flavone derivative often used for supporting venous function. Since venous disorders have been linked with RLS, diosmin is a promising possible treatment.
• Green coffee extract. Diabetes and pre-diabetes are known risk factors for RLS. Green coffee extract may help maintain healthy glucose levels.
• Valerian root. Valerian, an herbal sedative, is often used as a sleep aid. In a clinical trial, supplementation with valerian resulted in improvements in RLS symptoms and less daytime sleepiness.
• Other natural interventions that may help relieve RLS symptoms include D-ribose and vitamins C and E.
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