Primary Ovarian Insufficiency (POI): Symptoms, Causes, and Support Options
Modified on Jan 08, 2026 |
Deirdre Layne
Primary Ovarian Insufficiency (POI) is the current medical term for what many people still call Premature Ovarian Failure (POF). The newer term is more accurate because ovarian function may fluctuate—some women with POI continue to ovulate occasionally, even after diagnosis.
POI describes a pattern where the ovaries stop working normally before age 40, often leading to irregular or absent periods, lower estrogen levels, and fertility challenges. While POI can feel similar to early menopause, it is not always permanent in the same way.
Key distinction: Menopause is typically permanent. POI may be intermittent, meaning symptoms and ovarian activity can come and go.
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