Jacqueline (New Jersey) on 06/17/2023:

Hi my.bame is Jacqui. I am now 82 years of age.

I had the worst neuroo as thick pain around 3026. Every time I P Bank, burning like fire, crushing. Electric shocks, etc. Had ne constantly scream. Cause not known. I am not diabetic but I have chronic Lyme disease with multiple co infections including Bartonella. I was on Gabapentin that worked initially but when it stopped was switched to lyrica and then horizonta. Nothing worked.
At the time I tried Aloa Lipoic Acid but it had no effect on relieving the pain, but the dosages I took were co miserably lower than 600 mg that I notice is now recommended.

Out of desperation I started to experiment with high dosages of Benfotiamine. It is a synthetic form of vitamin B1 so that it iis made fat soluable and it can enter the cell wall ( and therefore nerve cells) making it highly more effective than ordinary B1 ( thiamine(. It is known to be effective & often used for diabetic neuropathy.

I learned about it in 2005 because I had used it successfully then when I had neurologic pain in my left small toe. The usual dosage is about 300-600 mg.
At tt time I took a little more & it was successful in stopping the sensitivity and pain ( even a sheet touching the toe area would caue pain(). Eventually I stopped using it. (At the time I was not aware that I had chronic Lyme disease. I believe that is the main cause of my beuropsthy(

So, 11 years later when I had severe neuropathic pain in my legs ( surprisingly not in my feet until later on) I experimented with Benfotiamine. I was desperate and decided to take increasing amounts until hopefully the pain diminished. I found the correct dosage. 1,200 mg ( 4 300 mg capsules) every 4 hrs. I put it on a timer and took it at the middle of night. I remained on that dosage for four years. Sometimes I could decrease it. When I had Covid the neuropathy got worse and going back to 7,200 mg a day was not enough. I doubled, possibly tripled that dosage and the pain went away. Eventually I was able to decrease the dosage dramatically..

I have also found that grape seed extract, high in resveratrol also have dramatic improvement and with very high dosage ( about 1 tsp of the piwder - in a drink & extremely bitter) I could reduce the Benfotiamine. ( BTW, for years I took high dosages of tumetic, by the tablespoon very effective for my for arthritic pain but it had no effect on the beuropaty, (. Now I take tumetic 95% curcumin, excellent for inflammation & other things but I haven't noticed it helps neuropathy). Benfotiamine in very high dosages has multiple benefits. One is that it promotes angiogenesis ( regrowth of arteries). While I was on the gett high dosage for many years I was not aware I had a 99% blockage in the popital artery, the main artery from the knee down the keg. It was discovered accidentally because I had no pain at all which is miraculous. The blockage was removed in 2019 and afterwards I have read about a study done on mice in 2006 that it promotes angiogenesis and the reason I had no.pain is because the high dosage I was on for years created colkatety arteries in my legs and that is why I had no pain. I have also read Benfotiamine is good for most autoimmune diseases. including fibromyalgia and Croans disease.

I have been for many years on high dosage Benfotiamine plus many other supplements that I experiment with. I also had an EMG test a little over a year ago that showed severe sensory neuropathy in my legs, mild motor.neuropaty, & very Mild neuropathy in my arms and also carpel tunnel. About two months ago I repeated tan EMG. My last EMG tests show although it had not been severe I no longer have motor neuropathy in the legs . The severe sensory neuropathy in my legs is now mild. I no longer have mild neuropathy in my arms and there is no carpal tunbel. The neuroligist who performed this last EMG is doubtful that zi ever had neuropathy because he said it is impossible for nerves to regenerate. I am also sering another neurologist next week to go over as ll these findings and see what he has to say.

I apologised for typos. It is late at night, early morning & I am writing this on a cell phone. But I wanted to share this important information with you.
Also Sulbutiamine is another fat soluable analog of Viramin B1. It is capable of entering the blood brain barrier whereas Benfotiamine can not. I have found and studies support this too can help neuropathy but more studies have been performed with Benfotiamine.