Luvbug (Atlanta) on 07/30/2023
One post says they take HDM (high dose melatonin) of 106 mg+ at night but the Options to purchase melatonin below the post, only showed 10 mg capsules. I’m just confirming that 106mg+ of Melatonin is the appropriate dose and not a typo. Also any tips for finding the best melatonin would be appreciated . Thank you very much
Art (California) on 03/05/2023
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585202/
Here are some very relevant quotes from the review :
' Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. '
' Melatonin directly affects bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. '
' Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention, and treatment of postmenopausal osteoporosis. '
' Melatonin is increasingly valued by patients and clinicians due to its antioxidant and antiaging properties. In our previous study, we determined that serum melatonin levels were obviously decreased in postmenopausal women with osteoporosis (Cao et al., 2022). '
' Melatonin is a mild osteogenic drug with few complications and has the potential and prospect of being an effective drug for the treatment of osteoporosis. '
' Therefore, serum melatonin measurements might become a new diagnostic standard for the prediction of the risk of postmenopausal osteoporosis. In fact, they could replace conventional dual energy X-rays, which would reduce economic costs and improve detection efficiency. '
' Melatonin treatment positive affected the increase in bone mineral density and the improvement in body mass index (Treister-Goltzman and Peleg, 2021). However, oral estrogen could inhibit nocturnal melatonin release in postmenopausal women (Okatani et al., 2000). '
Given the above, it is becoming very clear that melatonin is of significant value when it comes to osteoporosis and given its very good safety profile when compared to the latest class of drugs for osteoporosis, Bisphosphonates, it seems like a good choice.
Here is a list of Bisphosphonates which include Fosamax, Actonel, Boniva, Reclast and Aredia .
This link is for Fosamax side effects :
https://www.drugs.com/fosamax.html#side-effects
Here is a list of side effects :
Get emergency medical help if you have signs of an allergic reaction to Fosamax: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using Fosamax and call your doctor at once if you have:
chest pain, new or worsening heartburn;
difficulty or pain when swallowing;
pain or burning under the ribs or in the back;
severe heartburn, burning pain in your upper stomach, or coughing up blood;
new or unusual pain in your thigh, hip or groin;
jaw pain, numbness, or swelling;
severe joint, bone, or muscle pain; or
signs of low calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).
Common Fosamax side effects may include:
heartburn, upset stomach;
stomach pain, nausea;
diarrhea, constipation; or
headaches; or
bone pain, muscle or joint pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Art
Art (California) on 04/08/2022
https://www.frontiersin.org/articles/10.3389/fphar.2022.851663/full
Here is a very relevant quote from the study :
>>> ' This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. ' <<<
Art
Anne (Guilliers, France) on 03/18/2021
I’ve really appreciated your new melatonin piece. I use a tiny dose every night 1.8 which over time has improved my mood, too. I hope you don't mind me using your thread to point out i5 is low progesterone that most women suffer, not low estrogen. This is a common but crucially important mistake that needs correcting everywhere we can.
Progesterone is a precursor to estrogen and hardly ever mentioned. Look up Dr. John Lee pioneer in the study of natural progesterone. Our bodies are actually so overloaded with estrogen from what we eat and outside sources (Xeno estrogen) that it leads to varying problems like bone weakness, thyroid problems, overweight, diabetes. Our hormones are completely out of balance which obviously is disruptive to our endocrine system. I could go on but this is your post about melatonin and just wanted to point this out in the hope it will be read and picked up by the many people who are affected by it.
Thank you. Anne
BellaPaolina (Texas) on 03/17/2021
Please continue illustrating the earth clinic readers with your very interesting posts.
How are you feeling after your COVID 19 experience?
Joseph A. (San Bruno, Ca) on 03/17/2021
Elaine (Millerstown, PA) on 03/17/2021
I just finished reading your interesting article on melatonin. I know you can't prescribe, but could you suggest a dosage that I could begin with? Any recommendation would be helpful as I do not have medical coverage right now.