Skullcap, Nettle & DAO Enzymes for High Histamine

5 star (1) 
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Aleksandra (Canada) on 08/07/2026:
5 out of 5 stars

I developed this issue with histamines during candida overgrowth that began over 2 years ago, which is now resolved. Unfortunately, the histamine issues remain. I didn't realize that I was even having histamine issues until months after the fact because many of the candida symptoms I was experiencing were very similar.

The histamine issues are related to leaky gut, which I am self-treating with marshmallow root, slippery elm, cranesbill, glycine & glutamine. I take a blend of this first thing in the morning & 2 more times again throughout the day, on an empty stomach, in plain water.

I am also having very good results with the skullcap & nettle tea, as well as the DAO enzymes I chose, as a means of helping my body process histamines & decreasing histamine release. I drink the skullcap / nettle infusion 20 minutes before meals, as well as before bed. This is making a huge difference for me. I buy the skullcap & nettles as loose herb or sometimes harvest the nettles fresh. Nettles can also be eaten, cooked, or added to smoothies with great results.

I opted for DAO enzymes made from pea sprouts over the pig or cow kidney type because there is no way of knowing what kinds of residual hormones, antibiotics etc might be in the animal organs used for DAO supplements, which could cause additional problems. It took a few days for them to kick in, but they are working.

I have also begun sprouting my own pea seeds (those meant for sprouting, not the ones sometimes found in bulk from garden centers) to obtain fresh DAO enzymes as pea shoots are high in DAO, which taste great & are a good source of nutrients. They're very nice added to salads, in sandwiches and wraps & just to snack on.

Lastly, I am taking supplements: methylated B complex, extra B6, zinc / copper, magnesium, iron, vitamin C, along with several others.

The above is really assisting me in healing my gut. I am beginning to slowly add back in the foods I eliminated while dealing with candida, testing how my body reacts. So far, so good 👍

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