Natural Remedies for High Histamine (Histamine Intolerance & Mast Cell Support)

High histamine can show up as flushing, itching, hives, headaches, nasal congestion, heart palpitations, anxiety, and digestive upset. Whether you’re exploring histamine intolerance or supporting mast cell balance, this guide covers diet, supplements, probiotics, and lifestyle strategies many people use to find relief.

Common Symptoms & Clues

  • Skin: itching, hives, flushing, eczema flares
  • Head & sinuses: headaches, sinus pressure, nasal congestion
  • Heart & mood: palpitations, anxiety, irritability, sleep difficulty
  • Digestion: reflux, nausea, bloating, diarrhea/constipation
  • Other: temperature intolerance, menstrual sensitivity, exercise or heat-triggered flares
Tip: Symptoms that worsen after certain meals (fermented, aged, or leftover foods) or alcohol may point toward histamine load issues.

Low-Histamine Eating: Foods to Choose & Limit

Diet is the first line for most people. Histamine content varies by freshness, storage, and fermentation level. Aim for simple, fresh meals and limit leftovers (or freeze the extra right away).

Foods Generally Lower in Histamine

  • Fresh meats & poultry (cook or freeze the day you buy)
  • Fresh white fish (previously frozen is often better tolerated)
  • Most fresh vegetables: zucchini, carrots, cucumbers, sweet potatoes
  • Most fruits: apples, pears, blueberries, mango
  • Gluten-free grains: rice, oats, quinoa
  • Fats: olive oil, coconut oil, ghee (if tolerated)
  • Herbs: thyme, rosemary, basil, ginger, turmeric

Foods Often Higher in Histamine

  • Aged cheeses; fermented foods (sauerkraut, kimchi, soy sauce)
  • Alcohol, especially red wine and beer; vinegar
  • Cured meats, smoked fish, canned fish
  • Leftovers kept too long; long-simmered bone broth
  • Tomatoes, spinach, eggplant, avocado
  • Citrus, strawberries, chocolate

Smart Kitchen Habits

  • Buy & freeze fresh proteins in meal-size portions; thaw as needed.
  • Cook once, freeze once: if you batch-cook, freeze portions the same day.
  • Short simmer times: choose quick soups/stews over long bone broths.
  • Rotate foods to reduce sensitization and nutrient gaps.

Top Natural Supplements for High Histamine

Always introduce supplements one at a time and start low. If you take prescription medications, discuss changes with your clinician.

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