Gilbert syndrome is a common inherited condition that causes mildly elevated levels of bilirubin in the blood. Some people occasionally notice a yellow tint to the whites of their eyes or skin, particularly when bilirubin rises.

Although Gilbert syndrome involves bilirubin processing in the liver, it is not considered progressive liver disease and usually requires no treatment. For most people, the most useful approach is understanding what causes bilirubin levels to temporarily rise and minimizing those triggers when possible.

What Causes Gilbert Syndrome?

Bilirubin is produced when the body breaks down old red blood cells. Normally, the liver processes bilirubin so it can be eliminated from the body.

People with Gilbert syndrome have reduced activity of an enzyme called UGT1A1, which helps process bilirubin. As a result, unconjugated bilirubin can temporarily accumulate in the bloodstream.

Gilbert syndrome is genetic. It is not caused by poor diet, toxin accumulation, alcohol use, or inadequate liver detoxification.

What Triggers Higher Bilirubin?

Bilirubin levels in Gilbert syndrome naturally fluctuate. Common triggers include:

• Fasting or skipping meals
• Very low-calorie diets
• Dehydration
• Illness or infection
• Stress
• Strenuous exercise
• Menstruation

For some people, avoiding these triggers reduces episodes of visible jaundice.

Natural Ways to Support Well-Being

Because Gilbert syndrome itself usually does not need treatment, lifestyle measures are primarily aimed at avoiding known triggers and supporting general health.

• Stay well hydrated: Dehydration can increase bilirubin levels.
• Eat regularly: Fasting and severe calorie restriction can trigger higher bilirubin.
• Eat a balanced diet: There is no special Gilbert syndrome diet, but a varied diet provides nutrients needed for overall health.
• Manage stress: Stress can trigger higher bilirubin in some people.
• Exercise sensibly: Regular activity is beneficial for general health, although unusually strenuous exercise can temporarily increase bilirubin.
• Get adequate sleep: Consistent sleep supports general health and may make other triggers easier to manage.

What About Supplements and Herbs?

Earth Clinic readers have discussed supplements such as milk thistle, turmeric, NAC, selenium, alpha-lipoic acid, and other products commonly marketed for liver support.

These substances have been studied for various biological effects, but that does not mean they have been shown to treat Gilbert syndrome or reliably lower bilirubin in people with the condition. Evidence specifically demonstrating a meaningful benefit for Gilbert syndrome is limited.

When Yellow Eyes Need Medical Evaluation

A yellow tint to the whites of the eyes can occur with Gilbert syndrome, but jaundice has many other possible causes. It should not automatically be attributed to Gilbert syndrome unless the condition has been properly diagnosed.

New or unexplained jaundice, persistent abdominal pain, dark urine, pale stools, significant itching, fever, vomiting, unexplained weight loss, or other new symptoms warrant medical evaluation.

About the Reader Reports Below

Earth Clinic readers below discuss their experiences with Gilbert syndrome and approaches they have considered for elevated bilirubin or yellowing of the eyes.

These reports are personal experiences and may include supplements or theories that have not been clinically demonstrated to treat Gilbert syndrome. They should be considered anecdotal rather than evidence that a particular remedy lowers bilirubin or corrects the underlying condition.

If you have Gilbert syndrome, we invite you to share what seems to trigger changes in your bilirubin or jaundice and which lifestyle strategies have been helpful for you.