Melatonin for Diabetes Type II

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Art (California) on 04/21/2025:
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This new study (March 2025) shows how people with Diabetes Type 2 Mellitus (T2DM) have lower levels of Melatonin and higher levels of Chemerin and IL-1, both of which are inflammatory mediators, when compared to non diabetic people in the control group. The study further showed that use of melatonin lowered the level of Chemerin and further suggests that Chemerin may play a role in blocking melatonin production :

https://journals.lww.com/jfmpc/fulltext/2025/03000/to_determine_melatonin, _cytokines, _and_sleep_index.8.aspx

Here are some relevant quotes from the study :

' In the global sleep quality measure (PSQI questionnaire), the control group did better than the T2DM group, indicating lower sleep quality and a greater incidence of sleep problems. Melatonin production lacked rhythmicity and was lower in patients with T2DM than in controls both during the day and at night. The T2DM group showed greater levels of chemerin, IL-1, and a negative connection between melatonin and chemerin levels than the control group. '

' The results suggest that the low melatonin production seen in the T2DM group was most likely the underlying cause of the sleep pathology seen there. It is most probable that high levels of chemerin, which have been linked to other pathologies in the past, are to blame for the blocking of melatonin production in T2DM. '

' The global mean PSQI score for those with T2DM was 7.3 ± 33.3, whereas it was just 3.91 ± 1.1 for those without the disease, which means that the T2DM group slept less well]. In addition, 81.81% more people in the T2DM group had sleep problems than those in the control group (62.72%) . '

' The recent research found that 90% of diabetic patients suffer from some kind of sleep disruption, which is much greater than the incidence of sleep disturbance earlier documented in other illnesses (59% in age- and sex-matched control participants). Sleep quality affects vitality and morbidity and therefore plays a crucial role in overall health.[17, 18] The fact that the diabetes complication of insomnia affects many people underscores its seriousness. Previous research on other conditions has also shown that sleep disorders cause daytime sleepiness and problems with many functions such as the immune system and heart health.[17, 19, 20] '

Recently I posted about how melatonin can help heal diabetic wounds here :

https://www.earthclinic.com/cures/leg_ulcers2.html#melatonin

This 2025 meta analysis of 8 qualifying studies indicates that melatonin allows better glycemic control in T2DM patients :

https://pubmed.ncbi.nlm.nih.gov/39428939/

Here is a relevant study quote :

' According to the results of the current meta-analysis, persons with type 2 diabetes who supplement with melatonin had improved glycemic control. It looks that supplementing with melatonin at a dose exceeding 6 mg daily for over a period of 12 weeks may be more successful than other forms of intervention. '

Overall, it appears that melatonin is worthy of consideration and discussing with your doctor for T2DM.

Art

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