Astaxanthin for tinnitus is an intriguing natural approach first brought to Earth Clinic's attention by a reader who reported improvement in his inner-ear symptoms after taking a low-dose astaxanthin supplement.
Astaxanthin is a red-orange carotenoid with powerful antioxidant and anti-inflammatory properties. Research suggests that oxidative stress can contribute to damage within the inner ear, and experimental studies have found protective effects from astaxanthin in the cochlea. However, astaxanthin has not yet been proven in human clinical trials to treat tinnitus.
In 2019, William from Nashville, Tennessee, reported that taking a 2 mg astaxanthin softgel once daily helped his tinnitus. He described the effect as helping to "relax" his inner ear and also noticed benefits to his eyesight. ...
Astaxanthin for tinnitus is an intriguing natural approach first brought to Earth Clinic's attention by a reader who reported improvement in his inner-ear symptoms after taking a low-dose astaxanthin supplement.
Astaxanthin is a red-orange carotenoid with powerful antioxidant and anti-inflammatory properties. Research suggests that oxidative stress can contribute to damage within the inner ear, and experimental studies have found protective effects from astaxanthin in the cochlea. However, astaxanthin has not yet been proven in human clinical trials to treat tinnitus.
In 2019, William from Nashville, Tennessee, reported that taking a 2 mg astaxanthin softgel once daily helped his tinnitus. He described the effect as helping to "relax" his inner ear and also noticed benefits to his eyesight.
His experience came with an important caution: William discovered that he was allergic to astaxanthin at supplemental doses and stopped taking the regular astaxanthin supplement.
He later reported using Antarctic krill oil containing much smaller amounts of naturally occurring astaxanthin. According to William, the lower intake allowed him to continue experiencing some of the inner-ear and eyesight benefits without the more significant reaction he experienced with higher-dose astaxanthin supplements.
This is one person's experience and does not establish that astaxanthin treats tinnitus. However, it raises an interesting question: could astaxanthin's antioxidant effects help protect the inner ear in some people?
Tinnitus is the perception of ringing, buzzing, humming, hissing, or other sounds when there is no corresponding external sound.
It is a symptom rather than a single disease and can have many causes, including hearing loss, noise exposure, medications, ear disorders, jaw problems, vascular conditions, and changes within the auditory nervous system.
Oxidative stress is also being investigated as one factor involved in tinnitus and hearing damage.
The cochlea contains delicate sensory hair cells and nerve structures that can be damaged by excessive reactive oxygen species. This has led researchers to investigate whether antioxidants can help protect auditory structures or influence tinnitus symptoms.
Astaxanthin is a naturally occurring carotenoid pigment produced primarily by microalgae. It gives salmon, trout, shrimp, krill, and other marine organisms their characteristic pink or reddish color.
Unlike some other carotenoids, astaxanthin does not convert to vitamin A in the body.
Astaxanthin has attracted considerable research interest because of its antioxidant and anti-inflammatory properties and its ability to interact with cell membranes throughout the body.
Some of the most relevant research involves ototoxicity, which is damage to the inner ear caused by certain medications or chemicals.
Cisplatin, a chemotherapy medication, can generate substantial oxidative stress within the cochlea and cause permanent hearing damage. In animal and laboratory studies, astaxanthin has reduced oxidative stress and helped protect cochlear hair cells and other inner-ear structures from cisplatin-related damage.
This is important mechanistic evidence, but it is not the same as demonstrating that astaxanthin can reverse tinnitus in humans.
Astaxanthin itself has not been adequately tested in clinical tinnitus trials, but antioxidants more broadly have been studied.
In one randomized, double-blind, placebo-controlled study involving 70 people with tinnitus, a combination of antioxidant supplements improved several measures of tinnitus compared with placebo.
The study used multiple antioxidants rather than astaxanthin alone, so the results cannot be attributed to astaxanthin. They do, however, support continued investigation of oxidative stress and antioxidant status in tinnitus.
At present, there is not enough human evidence to answer this question with certainty.
William's Earth Clinic report suggests that some individuals may notice a change, while laboratory research provides a plausible biological reason to investigate astaxanthin further. Neither provides proof of effectiveness.
Tinnitus also has many different causes. An antioxidant might theoretically be more relevant when oxidative stress or inner-ear injury is involved than when tinnitus originates primarily from another cause.
There is no established astaxanthin dosage for tinnitus.
William reported improvement while taking 2 mg daily, but this was his personal experience rather than a clinically established treatment dose. He also subsequently experienced an allergic reaction, illustrating why an individual reader's dosage should not automatically become a general recommendation.
Astaxanthin supplements are sold in a wide range of strengths. Because tinnitus-specific clinical trials have not established an effective dose, there is currently no evidence that taking a larger amount will produce a greater benefit.
Astaxanthin is fat-soluble and is generally taken with food containing some dietary fat to aid absorption.
William later switched to krill oil that provided a much smaller amount of astaxanthin per softgel. Krill naturally contains astaxanthin, although the amount varies considerably among products.
Krill oil also contains omega-3 fatty acids, so any effects noticed while taking krill oil cannot necessarily be attributed specifically to astaxanthin.
People with seafood or shellfish allergies should be particularly cautious with krill-derived products.
Astaxanthin is generally well tolerated in amounts commonly found in supplements, but individual reactions can occur.
Possible adverse effects include digestive upset and changes in stool color. Allergic reactions are also possible, as William's experience illustrates.
Stop taking a supplement and seek appropriate medical attention if symptoms of a significant allergic reaction develop.
Concentrated supplements may also affect blood pressure, blood sugar, immune activity, or blood clotting. People taking prescription medications, particularly blood thinners or immunosuppressants, should check for potential interactions before using astaxanthin supplements.
Tinnitus is common, but certain forms deserve prompt medical evaluation.
Seek medical attention for tinnitus that develops suddenly, occurs with sudden hearing loss, affects only one ear without an obvious explanation, pulses in time with the heartbeat, or is accompanied by significant dizziness, neurological symptoms, or ear pain.
Sudden hearing loss accompanied by tinnitus should be evaluated urgently because early treatment can sometimes affect the likelihood of hearing recovery.
Earth Clinic would like to hear from readers who have tried astaxanthin for ringing, buzzing, or other sounds in the ears.
If you have used astaxanthin, please tell us the amount you took, how long you used it, what type of tinnitus you have, whether you have hearing loss, and how long it took before you noticed improvement, worsening, or no change.
Detailed experiences can help build a more useful picture of how people are using astaxanthin for tinnitus while clinical research continues to catch up.
