Posted By peter (chicago) on 07/26/2022

My wife has has high creatinine, can you recommend what to take lower the level? Trying to avoid dialysis.

Replied by Peter (Chicago) on 07/27/2022

She has been taking for last 4 months Torsemide 100 mg one a day, hydralazine 100 mg 3 times a day plus kidney rejection medicine, her creatinine and bunn increased on the last test. Her blood pressure has been stabilize only by taking the carditone, right now the issues are blood sugar and creatinne/bunn. Any help would be appreciated. Thanks Art.

Replied by Art (California) on 07/28/2022

Peter,

A bit more useful information on your part.

Glad to hear that the Carditone brought her blood pressure in range.

Melatonin should still be a consideration, but also look into Berberine, a supplement that is often used by diabetics to lower blood sugar and HbA1C, while improving insulin sensitivity, but it also has shown the ability to lower high Bun and Creatinine levels in animals :

https://www.dovepress.com/effect-of-berberine-on-hyperuricemia-and-kidney-injury-a-network-pharm-peer-reviewed-fulltext-article-DDDT

Here is a relevant quote from the study :

>>> ' In the in vivo experiment, BBR substantially decreased the level of UA, BUN and CRE, and alleviated the kidney damage in mice with HUA. BBR reduced IL-1β and IL-18, and downregulated expressions of NLRP3, ASC, Caspase1 and IL-1β. BBR also inhibited expression of URAT1 and exhibited strong affinity with this target in silico docking. ' <<<

In animal studies melatonin has also shown the ability to lower elevated Bun and Creatinine levels while offering kidney protective effects :

https://www.frontiersin.org/articles/10.3389/fphys.2021.791036/full#:~:text=Our findings indicated that melatonin, R injury in animals studies.

Here is a relevant quote from the study :

>>> ' Our findings indicated that melatonin can significantly improve renal function (BUN and SCr) and reduces oxidative stress (decreasing MDA and MPO, increasing SOD and GSH) of renal post-I/R injury in animals studies. ' <<<

These two would be worth discussing with her doctor to see if they would be compatible with her current medications. Both have very good safety profiles and both offer kidney protective effects among a multitude of other health effects including potent anti inflammatory and antioxidative stress effects.

Art

Replied by peter (chicago) on 07/31/2022

Art

Thanks!

What kind of dosage of melatonin and berberine to take based on the study?

My wife also has a lot trouble sleeping and she is currently taking the melatonin with B vitamin B6 that you wrote on your older post. I think because she is on so many medication is the main problem. Is there something stronger? She was hospitalized over 4 months and just got out 2 months ago.

Peter

Replied by Art (California) on 08/01/2022

Peter,

Using human studies for other health issues, you can get an idea of the dosages that have been used to good effect in humans as opposed to animals. In the following melatonin study at 10 mg/night, melatonin was shown to noticeably improve antioxidant and inflammatory parameters in people with Parkinson's Disease :

https://www.sciencedirect.com/science/article/abs/pii/S0303846720302213?via=ihub

A quote from the study :

>>> ' Overall, melatonin supplementation for 12 weeks to patients with PD had favorable effects on the UPDRS part I score, PSQI, BDI, BAI, hs-CRP, TAC, GSH, insulin levels, HOMA-IR, total-, LDL-cholesterol, and gene expression of TNF-α, PPAR-γ and LDLR, but did not affect other metabolic profiles. ' <<<

In this melatonin animal study review and meta analysis :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793910/

They reached the following conclusion :

>>> ' From the available data of small animal studies, this systematic review demonstrated that melatonin could improve renal function and antioxidative effects to cure renal I/R injury through, then multiple administration of melatonin might be more appropriate. Nonetheless, extensive basic experiments are need to study the mechanism of melatonin, then well-designed randomized controlled trials to explore the protective effect of melatonin. ' <<<

So you can see the potential of melatonin from the animal study and then get an idea of how that benefit translates to humans in the human study of melatonin in people with PD.

As regards Berberine in humans :

This Healthline article gives a good idea of what is known regarding the use of Berberine in humans :

https://www.healthline.com/nutrition/berberine-diabetes#dosage

Here is a quote from the article :

>>> '

There’s currently no established dosage for berberine supplements.

However, most studies have administered 1, 000–1, 500 mg per day (3Trusted Source, 9Trusted Source).

Berberine has a half-life of several hours, so it doesn’t last in your system for too long. Most berberine supplements contain 500 mg per capsule, and supplement labels often recommend taking berberine 3 times per day before meals (12).

This equates to taking a total of 1, 500 mg daily.

Berberine is available in powder or capsule form and can be purchased from health stores and online.

That said, you should always work with your healthcare provider before adding berberine to your daily routine. ' <<<

In the following systematic review and meta analysis of randomized controlled trials (RCTs) of Berberine in diabetes patients, Berberine was shown to be beneficial :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8696197/

Here is a relevant quote from the meta analysis of Berberine in diabetic patients :

>>> '

Forty-six trials were assessed. Analysis of berberine applied alone or with standard diabetic therapies versus the control group revealed significant reductions in HbA1c (MD = -0.73; 95% CI (-0.97, -0.51)), FPG (MD = -0.86, 95% CI (-1.10, -0.62)), and 2hPG (MD = -1.26, 95% CI (-1.64, -0.89)). Improved insulin resistance was assessed by lowering FINS (MD = -2.05, 95% CI (-2.62, -1.48)), HOMA-IR (MD = -0.71, 95% CI (-1.03, -0.39)), and BMI (MD = -1.07, 95% CI (-1.76, -0.37)). Lipid metabolisms were also ameliorated via the reduction of TG (MD = -0.5, 95% CI (-0.61, -0.39)), TC (MD = 0.64, 95% CI (-0.78, -0.49)), and LDL (MD = 0.86, 95% CI (-1.06, -0.65)) and the upregulation of HDL (MD = 0.17, 95% CI (0.09, 0.25)). Additionally, berberine improved the inflammation factor.

Conclusion: There is strong evidence supporting the clinical efficacy and safety of berberine in the treatment of DM, especially as an adjunctive therapy. In the future, this may be used to guide targeted clinical use of berberine and the development of medications seeking to treat patients with T2DM and dyslipidemia. ' <<<

Because of the serious nature of your wife's condition, it is important that her doctors and other medical professionals are made aware of any plans for treatment the two of you may consider.

Art

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