Replied by Art (California) on 11/15/2024
Hi Lee, Grapefruit Seed Extract (GSE) is a potent staphylococcus aureus (SA) inhibitor as well as an SA biofilm fighter, as discussed here :
https://pmc.ncbi.nlm.nih.gov/articles/PMC7830962/
Here is a relevant study quote :
' GSE showed antibacterial effects against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) in the disk diffusion test. Even at the lowest concentration, GSE showed antibacterial activity in the microdilution MIC test. As a result, we can conclude that GSE is a naturally derived antibacterial substance that exhibits a favorable antibacterial effect even at a very low concentration, so it is a good candidate for a natural substance that can be used to prevent or reduce nosocomial infections as coating for materials used in medical contexts or by mixing a small amount with other materials. '
And Here :
https://www.jmb.or.kr/journal/view.html?uid=5244&vmd=Full#:~:text=GSE had a significant degradation, 1B).
Here is a relevant study quote :
' GSE had a significant degradation effect on mature S. aureus and E. coli biofilms at 1/2 × MIC (12.5 µg/ml) and 1/8 × MIC (31.25 µg/ml), respectively (p < 0.05; Fig. 1B). '
Xylitol also inhibits SA and MRSA bacteria and biofilm as discussed here :
https://link.springer.com/article/10.1007/s00284-024-03799-2#:~:text=The present study showed xylitol, were studied separately or together.
Long term SA infections can develop biofilms which protect the SA bacteria from the bodies own antibacterial mechanisms as well as many antibiotics, so having the ability to breakdown biofilms is useful when fighting against SA and MRSA bacteria.
Given the above information, it is worth mentioning the nasal spray, called Xlear Nasal Spray contains both GSE and Xylitol. Here is an Amazon link to Xlear Nasal Spray (XNS) which is also available at many local drugstores :
https://www.amazon.com/Xlear-Nasal-Spray-Sinus-Relief/dp/B000M4W2E6/ref=sr_1_1?crid=1I3RAUQ0ZGC9J&dib=eyJ2IjoiMSJ9.PFUQN--GJRRCwUcdJLz7blcFVuirGiPQdQBaZvN6_p5jy3MuuHHE2BtVL41UQCX6wtP0SYP44P5SvM46Wq_dfrvuuyMO-sF1JjSgnxr27mlNTtA0HNJ9FSBqT5i8FbwtbhF7VgwqmtaaFpdOs0Z6g0CgFQQ4loQJ6w7ZfNLVZNz95JDweznArpu58wnhHYfGydWQZQtJJS3EasdRmibBCOOK0li7VzmwJWsaINZcxBJp9NkN7tvfqGguNxKdAAALb5SBv-lkhXSZznL22MBSfU81fmy-Nq7k8I1CXvMQsrA.YSyKdJVVct-yt5T7JNuzCP4ta6_4FLN78KwVMnGUqPg&dib_tag=se&keywords=xlear+nasal+spray+with+xylitol&qid=1731721926&sprefix=xlear+nasal+spray.,aps,147&sr=8-1
Please read some of the over 33, 000 reviews to get a better idea of what people think of XNS for multiple sinus issues including bacterial infections.
Art
