Replied by Art (California) on 12/25/2022
The supplement melatonin may be helpful for gastroparesis to help with motility issues by improving gastric transit according to the following study : https://jpp.krakow.pl/journal/archive/12_07_s6/pdf/97_12_07_s6_article.pdf
Here are two relevant quotes from the study :
' Low doses M improve gastrointestinal transit and affect MMC. '
Whereas high doses of melatonin delay gastric emptying as mentioned in this study quote :
' Pharmacological doses of M delay gastric emptying via mechanisms that involve CCK2 and 5HT3 receptors. '
Melatonin has also shown benefit for Idiopathic (from unknown cause) Thrombocytopenia Purpura (ITP) as discussed in this case report :
https://pubmed.ncbi.nlm.nih.gov/12424512/#:~:text=Toxicity was lacking, with the, in patients with refractory ITP.
Here is a relevant quote :
' This provided the rationale to evaluate melatonin for toxicity and efficacy in three patients with idiopathic thrombocytopenic purpura (ITP) refractory to initial treatment with corticosteroids or splenectomy (refractory ITP). Patients received melatonin for 1 month. The therapy was continued for 2 additional months in patients with stable or responding disease. After 3 months, the stable or responding patients continued the therapy for 3 months and more. All patients had a partial response after 1 month. Continuing with the treatment, none of the three patients had disease progression (average follow-up time of 31 months; range: 23-46 months). Toxicity was lacking, with the only side effect being drowsiness. Our experience suggests that melatonin may be safe and effective in patients with refractory ITP. '
It is also worth mentioning that in gastroparesis, there are known deficiencies such as vitamin B1, vitamin B6(P5P) Vitamin, B12, vitamin D and iron which should be corrected as part of a treatment plan.
Art
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