Thanks.
Replied by Art (California) on 03/17/2026
Hi Jr, A three supplement combination of vitamin B6 as P5P, folate and vitamin B12 are a very good way to significantly lower high homocysteine levels. Here is a typical dosing range you can discuss with your doctor :
1. B6 As P5P - 5 – 25 mg / day
2. Folate as Methylfolate - 800–1000 mcg / day
3. B12 In the Methylcobalamin form ~20–500 mcg / day
In the alternative and for simplicity you can consider a vitamin B complex supplement that utilizes these three specific forms of these supplements in one supplement to discuss with your doctor. These B Complex forms are generally referred to as a "Methylated B Complex".
These complexes should be quite useful for lowering homocysteine levels as you have indicated you are interested in doing.
Art
Replied by Kate Pickle (Tulsa) on 03/17/2026
Trimethylglycine is made to lower and High homocysteine levels are usually the culprit in idiopathic high blood pressure.
