Replied by Art (California) on 10/27/2022
STEVEN, Melatonin may be additive to your current regimen in trying to help your Aortic Aneurysm based on this study :
https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12661
Here is a relevant quote from the study :
' Our study is the first to report that melatonin exerts therapeutic effects against TAAD by reducing oxidative stress and VSMC loss via activation of SIRT1 signaling in a receptor-dependent manner, thus suggesting a novel therapeutic strategy for TAAD. '
And this study :
https://pubmed.ncbi.nlm.nih.gov/28478022/
Here is a relevant quote from the study :
' On the one hand, MMP-2, MMP-9, tumor necrosis factor-α, and inducible nitric oxide synthase protein expressions were increased in the vehicle-treated AAA group. On the other hand, melatonin treatment reversed all of these biochemical indices and histopathologic alterations. '
These are both animal studies, but melatonin has a proven safety profile in humans at very high dosing.
Art
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