Fatty Liver and Crohn's Disease

Posted By Hazel (San Jose Ca ) on 02/10/2024

I recently received diagnoses of both fatty liver and Crohn’s disease from my doctor. I'm seeking insights and guidance on how to effectively manage these conditions and prevent them from worsening. Any advice you can offer would be greatly appreciated. Thank you.
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Replied by SVD (Chicago) on 02/11/2024

According to Mercola article choline is required to move fat out of your liver. Read his article:

https://www.facebook.com/doctor.health/posts/choline-is-required-to-move-fat-out-of-your-liver-making-it-an-essential-nutrien/10156882356480590/

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Replied by Art (California) on 02/11/2024

Hi Hazel,

Berberine is useful for fighting NAFLD as well as Crohn's disease(CD) via manipulation of the gut microbiome and reduction of inflammation and oxidative stress markers. Here is a review article of multiple studies confirming the use of Berberine for CD :

' https://www.sciencedirect.com/science/article/abs/pii/S1043661816306156#:~:text=The antinociceptive and antidepressant-like, to IBD-specific immunological effects

Here is a relevant quote :

' Berberine, both in its pure form and as principal constituent in medicinal plants, has been shown to display numerous pharmacological activities including analgesic [8], anti-inflammatory [9], anticancer [10], antidiabetic [11], anti-hyperlipidemic [12], cardioprotective [13] and memory enhancement and antidepressant [14], [15], [16] effects. The antinociceptive and antidepressant-like activity of berberine has been shown to serve as a mechanism of action for its therapeutic use in treating inflammatory bowel disease (IBD) [17], [18] though numerous other mechanisms ranging from general anti-inflammatory and antioxidant to IBD-specific immunological effects are implicated. '

And for NAFLD :

https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-017-0165-7#:~:text=BBR improved NAFLD by inhibiting, NAFLD and glucose metabolic disorder.

Here is a relevant quote from research article :

' BBR improved NAFLD by inhibiting glucogenesis and comprehensively regulating lipid metabolism, and its effect on inhibiting hepatic lipogenesis was much stronger. The improvement may be partly mediated by weight loss. Berberine might be a good choice for patients with NAFLD and glucose metabolic disorder. '

Additionally low dose naltrexone (LDN), a prescription medication will also work against both diseases. Here is a link to LDN for Crohn's disease :

https://academic.oup.com/ibdjournal/article/28/Supplement_1/S106/6514035

Two relevant study quotes :

' Colonoscopy showed dramatic improvement of rectal ulcerations and 3 small erosions in the proximal ascending colon which were not present on the previous colonoscopy (Figure 1B). At the time of this colonoscopy he was doing well clinically with a plan to augment LDN therapy with a probiotic and an anti-inflammatory diet. This case demonstrates favorable clinical and endoscopic response to an LDN-based regimen that was rapid and durable, with a short exposure to steroid. '

' Within 4 months, her symptoms were in remission and ileoscopy showed flat scars where ulcers had been seen in the past (Figure 2B). Her disease remained in endoscopic remission for 3 years documented by two more ileoscopies. The patient maintained clinical response to the combination of infliximab (6 week intervals), methotrexate, and LDN. Owing to a change in insurance she was lost to follow up at this point. '

For LDN and NAFLD :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9168111/

Here is a relevant quote :

' Naltrexone can effectively reduce bodyweight and adipose tissue accumulation, reduce liver fat lesions, improve the expression of lipid metabolism-related proteins and endoplasmic reticulum stress, reduce liver lipid synthesis, and protect liver cells. '

Your doctor should be willing to prescribe LDN because of its excellent safety profile alone. Berberine is available from almost all supplement suppliers.

Art

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Replied by Hazel (San Jose Ca ) on 02/11/2024

​​Thank you, Art, for dedicating your time and effort to gather such valuable information to assist me in improving my health. I've also been informed that my liver is mildly enlarged. Could you provide any advice on managing an enlarged liver? Your support is greatly appreciated.

Replied by Art (California) on 02/11/2024

Hi again, Hazel and you are welcome!

Your NAFLD may be approaching the more advanced stage of, nonalcoholic steatohepatitis (NASH) which involves elevated inflammatory and oxidative stress levels of the liver which can cause swelling of the liver. To put more effort into control of the NAFLD, you may also consider melatonin and astaxanthin as I wrote about here for NAFLD and interestingly both are suggested to be beneficial for IBD/Crohn's disease :

https://www.earthclinic.com/cures/nonalcoholic-fatty-liver-disease.html

Art

Replied by Hazel (San Jose Ca) on 02/11/2024

Your articles on melatonin and other supplements to aid in reversing fatty liver have been incredibly insightful. Your presence in the Earth Clinic community is truly invaluable, and we're immensely grateful for your knowledge and wisdom. Sending you love and light as a token of our appreciation

Replied by ABC (Chicago) on 02/13/2024

Boiron Nux Vomica 30C Homeopathic Medicine helps to rectify many of the liver ailments. Here, Nux Vomica is prominently indicated for an enlarged liver, fatty liver, jaundice, and hepatitis. The liver is swollen, sore and tender to pressure. Sticking, shooting, stinging, stitching, sharp or throbbing pain in the liver is felt. Motion worsens the pain. Tightness and constriction in the liver area is also present. Diarrhea and vomiting appear from liver complaints. Loss of appetite and aversion to food appears. Liver weakened from excessive alcohol intake, drug abuse also points towards the use of this remedy. Apart from above, Nux Vomica is preferable medicine for gallstones.
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