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Timh (Ky) on 11/07/2015: 
Dr. Tennenbaum has some good insights into adrenal fatigue and posting on I-HealthTube lately. Reducing sugar & stress are his top notes.
Back to fatigue & hormones. Pituitary & Hypothalamus are the top two glands and then Thyroid & Adrenal. So, it is worth the effort to try a broad-spectrum Women's Multiglandular supplement for a more balanced effect. Coconut Oil & Iodine support Thyroid & Adrenal. Dong Quai is an excellent female herb worth taking. GABA fuels the Pituitary and increases HGH & IGF-1.
Detoxing & cleansing may be necessary, as well as antioxidant nutrition.
Jan (USA) on 08/14/2007:
Ted (Bangkok, Thailand) on 03/01/2004:
Q: What is the dosage of manganese per day ?
A: It is often NOT taken per day.
Manganese overdose is relatively difficult if common sense principles are applied which is basically taken when it is needed only and most remedies are taken relatively infrequent, and yet, if it does work, it is taken on an "as needed" basis.
The common dose is 25 mg and taken only once for hair loss, but also the tablets, assuming it is taken in that form are quite commonly poorly absorbed if for some reason, it is taken on an empty stomach.
In event the next day hair loss reduction is noted, then it's working, the next step is to determine the exact dose, which usually means it is taken gradually and not everyday.
Some people who do take manganese noticed improvement in mood and reduction in depression, so they know how to monitor that one whenever those people are deficient. Optimum dose is not commonly pursued to avoid overdose, with the possible exception of suboptimal health.
The other issue is manganese should generally be taken in powdered, or the tablets are grounded or chewed so that the tablets which take that form with the addition of waxy substances such as manganese stearate(a wax) and calcium carboante, which prevents their absorption, also takes its toll on mineral bioavailability so the exact dose on as per label are always less if we consider how much of those gets absorbed when other waxes and fillers block them.
This has happened so often, that I lost count, this is perhaps my biggest concern with the supplements. And usually excesses or lack of it can be measured somewhat indirectly with the use of hair mineral analysis, which while it is not an exact science, is better than no information at all, especially in event of a heavy metal toxicity.
While dietary manganese level is 2 mg, most long term lack of it can result in negative levels of the body's stores for manganese, which is why in practice a single dose of 25 mg is taken just once a week, or in event of that manganese is confirmed to work, than it is taken on an "as needed basis" which can be like once a week until all conditions are gone, or in the event of a bad hair loss, it is taken for 4 days out of a week then it is stopped. It is stop because apparently the hair loss has been cured with that remedy.
The other problem about dietary manganese of 2 mg is that we are beating around the bush, how much DOES our body needs, and how much it is taken are two different things. The great divide is how well our body absorbed them which in practice, I suspect it is more closer to 10% of what is taken are absorbed, based on my optimistic projection. The older we get, the less we absorbed them so the body can end up being deficient across the board with the "essential minerals" while at the same time, being excessively loaded with free heavy metals that the body does not need.
For people with caution, natural sources of manganese are possible, but it must be understood that the level of manganese from natural sources varies, the biavailability can be limited, since manganese works best if taken alone on an empty stomach and it works synergistically with vitamin C and other problems such as destruction of mineral or mineral depletion due to processing of natural foods.
Rich manganese sources that is commonly used are soy milk, but nuts & seeds also have it. My own experience from eating nuts and seeds is the absorption to raise the manganese level is relatively very slow - like several months from those sources, while the other forms are relatively much more quicker, such as chelated amino acids of manganese, or chelated manganese. Sea salt rich in mineral is possibly another source, while the amount is quite small, its effect for a specific symptoms or sickness, won't resolve them quickly. It is therefore used when several mineral imbalances are noted that a sea salt will pull through or it is used as a supplements and the dose is fairly small which is 1/4 teaspoon of sea salt in one liter of water and can be taken often as people feel it is necessary.
