Art (California) on 07/14/2026

https://pmc.ncbi.nlm.nih.gov/articles/PMC12590877/

Here are two relevant quotes from the study :

' The reduction in ulcer size in the melatonin group was approximately twofold greater in compare with the placebo (mean reduction: -2.7 ± 0.4 cm² vs. -1.34 ± 0.39 cm²; p-value: 0.08). '

' Topical 1% hydrogel demonstrated efficacy and safety in reducing the number, grade, and size of DFUs when used as a complementary therapy alongside standard ulcer care. This approach may help prevent complications associated with non-healing ulcers thereby improving patients’ quality of life and functional independence.'

Using melatonin lotion over melatonin gel may offer longer usable time on the skin. I explain how to make the lotion at the link below, but in order to get closer to 1% mix used in the study, it may be better to use a " slightly heaping 1/4 teaspoon" of melatonin powder rather than " a level full 14 teaspoon". Here is a link to how I make melatonin lotion :

https://www.earthclinic.com/supplements/melatonin-lotion.html

Art