Art (California) on 06/27/2025

This newer study suggests that melatonin significantly decreases the risk of getting AMD while in existing cases melatonin had a negative impact on disease progression as discussed here :

https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2819801#:~:text=In this cohort study, melatonin, diagnosis and progression of AMD.

Here are two relevant quotes from the large cohort study :

; Melatonin use was associated with a decreased risk of development and progression of AMD. '

; Among patients aged 50 years or older, those in the melatonin cohort had a reduced risk of receiving an AMD diagnosis compared with the control cohort (RR, 0.42; 95% CI, 0.28-0.62). The analysis of the older subsets of patients revealed similar findings (aged ≥60 years: RR, 0.36 [95% CI, 0.25-0.54]; aged ≥70 years old: RR, 0.35 [95% CI, 0.23-0.53]). Such associations persisted even when patients were monitored for AMD development at least 2 years after the index event (aged ≥50 years: RR, 0.22 [95% CI, 0.12-0.39]; aged ≥60 years: RR, 0.40 [95% CI, 0.19-0.83]; aged ≥70 years: RR, 0.22 [95% CI, 0.12-0.43]). Likewise, our sensitivity analyses revealed consistent results with that of the primary analysis (eTables 6-8 in Supplement 1). The negative control outcome analysis showed that melatonin treatment was not associated with the risk of head injuries (eTable 9 in Supplement 1). '

The list of health benefits associated with melatonin use continues to grow significantly!

Art