Replied by Art from California on 06/25/2025
Hi Hollyhock,
In Polymyalgia Rheumatica (PMR) and the resulting Giant Cell Arteritis (GCA) elevated IL-6 (inflammatory cytokines), Erythrocyte Sedimentation Rate (ESR) and elevated C-reactive protein (CRP) inflammatory levels are a definite issue so looking for supplements that lower IL-6, ESR and CRP is important.
Although melatonin is an IL-6 and C-Reactive Protein (CRP) inhibitor, it may not be a good choice for these two health issues when combined with the standard corticosteroid therapy. Several known IL-6, ESR and CRP inhibitors are :
1. NAC @ 1200 mg/day total in two divided doses of 600 mg at breakfast and 600 mg at dinner
2. Curcumin @ at least 1000 mg/day
3. Omega 3s such as Fish Oil at 3 grams total per day
4. Astaxanthin @ 24 mg/day with a meal
5. Vitamin D to get well into the reference range for 25 OH d level of 30 ~ 100 ng/ml
The above mentioned dosing is based on studies for other health issues in humans than the two that are named.
Due to different methods of action among this group, there is also potential for synergy, which could be useful.
Due to the serious nature of the two named health issues, you will need to get your doctors approval and supervision in order to use the mentioned supplements.
Art
