Kh (Las Vegas, Nv) on 12/01/2013
She went from asking the same question every 60 seconds (for example, she would ask where my father was, we'd answer that he was in the hospital, then seconds later she'd ask again) and being unable to take a shower because she couldn't remember how to do it, to being 100% her old normal self pre-dementia.
She can now shower and dress herself and apply her own make-up. She is back to cooking my parents' meals. She keeps the house clean. She remembers answers to questions. She is able to participate in conversations. She remembers events of the past few years that she had completely lost. She knows what year it is. She knows her age and my father's age.
Also, she had gotten very erratic emotionally. Now she's got her old personality back.
She got it all back.
She had no trouble with side effects.
We've been tapering down her dosage to see how she handles it. Right now she's on 1000 mg time release 2x a day, and so far so good.
Replied by Kh from Las Vegas, Nv on 12/01/2013
Takes 4 Months to See ResultsI forgot to mention that it took just under four months for us to see what seemed to be a full cure, but we started to notice improvement even after a few days.
For example, my mother was able to remember that my father was in the hospital after about three days on niacinamide. She was able to remember how to shower after about a week and a half, but she still forgot where the soap was. She was able to remember where the soap was a few days later.
She was able to remember to feed the dogs (and what to feed them) after about three weeks. It took almost a month for her to remember what year it was and her age.
Replied by Shawna from Torrance, California on 12/01/2013
KH, that is wonderful!! WOW!!! Thank you so much for sharing. I am going to share this with everyone I know, including my parents!Replied by Francoise from Quebec, Canada on 01/31/2014
Hi KH,I am curious about the niacinamide supplement used for your Mother in curing her Alzheimer condition. All the ones I have looked at contain magnesium stearate which I understand blocks the absorption of the vitamin. One contained hypromellose, and though I have looked at various sites regarding the safety of this ingredient, I would really appreciate Earth Clinic's take on whether it is safe or not. Can you please tell us what brand was used for your Mom? Many thanks, Francoise
Replied by Tony from Tn, Usa on 01/31/2014
Hello Francoise from Quebec, Canada:Solaray makes a niacin supplement without magnesium stearate. PureBulk makes a powder form of niacin without any type of additives whatsover. Vitaspace is another powder without any additives as well.
I think the controversy about magnesium stearate is a little exaggerated but I still try to avoid it if possible. Here is a link to compare niacin supplements and their ingredients: http://www.toxinless.com/niacinamide
God Bless and hope you can find a niacin supplement to fit your needs.
Replied by Lynda from Europe on 05/02/2015
Hi, I have read Joyce, and Kh testimony in curing their parents Alzheimer , and it gave me hope. I would like to ask them today , after one year or so how are their parents? are they still well? are their conditions , stable?If you could answer my question or anyone who has tried the niacinamide, vitamin A , coconut oil and turmeric to share their experience please.
Thank you,
Lynda
Replied by Mg from Phoenix, Az on 03/22/2016
My father has dementia and is on Namenda XR and Donetezil HCL currently, but it is no longer working. I wanted to know if your mother was taking any medication when she started taking the niacinamide and if there is any danger in mixing his current meds and niaminacide?Replied by Zark from Emerald City on 05/19/2016
Here is a relevant abstract on this matter:Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
http://www.jneurosci.org/content/28/45/11500.abstract
Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or delay its onset are urgently needed. Effective preventive strategies likely offer the greatest and most widespread benefits. Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance memory and synaptic plasticity. We evaluated the efficacy of nicotinamide, a competitive inhibitor of the sirtuins or class III NAD+-dependent HDACs in 3xTg-AD mice, and found that it restored cognitive deficits associated with pathology. Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increased acetylated a-tubulin, a primary substrate of SirT2, and MAP2c, both of which are linked to increased microtubule stability. Reduced phosphoThr231-tau was related to a reduction of monoubiquitin-conjugated tau, suggesting that this posttranslationally modified form of tau may be rapidly degraded. Overexpression of a Thr231-phospho-mimic tau in vitro increased clearance and decreased accumulation of tau compared with wild-type tau. These preclinical findings suggest that oral nicotinamide may represent a safe treatment for AD and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability.
Replied by Dave from Fountain Inn, Sc on 05/19/2016
Thank you Zark;Zark cites an article; actually an abstract from the Journal of Neuroscience. For the ones who, like me, had to wade through the technicals, essentially it said that the non-flushing form of niacin/B-3, is really helpful in reducing the amount of "forgetfulness" associated with Alzheimer's. And interestingly the very next post discussed the same benefit in psychological issues referring the reader to a Doctor Mercola interview. From my perspective, I take the flushing form almost daily to ward off migraine attacks.
Replied by Maddie H. from Idaho on 10/02/2016
I was concerned when I read that removing amyloid plaque might make matters worse, so I looked up ultrasound for dementia which has been used successfully to improve the memories of mice in experiments conducted in Australia. I was relieved to read that the ultrasound removed plaque from the mice's brains, and instead of getting worse they improved. If nattokinase can cross the blood/brain barrier, seems it would be a much simpler way to improve an Alzheimer patient's memory.Replied by Mercy from Texas on 11/27/2016
Hi KH. I was wondering if you could give us an update on your Mother's condition? Thanks.Replied by Suzy from Indiana on 06/20/2017
Dave, I believe my mother would benefit from taking niacin. I take it daily and know it works. The problem I see is flushing. I don't think I could get her to take the niacin a second time. I read so much about how it has to be the flushing kind. Is that true? I don't understand the difference. Can you set me straight on this. Thank you for all you do for us on Earth Clinic.Replied by Trudy from South on 06/21/2017
As to taking the niacin, get a bulk powder of pure niacin. Measure it out so you get an ultra-small dose, say 10 mg or so. Get her used to that and then move it up as she tolerates it. I started at 25 mg once per day, then went 25 twice per day and them moved incrementally until now I take 1000 mg twice per day and don't really notice the flush. I just put it in food when it was a small dose, but now I put it in capsules for convenience.Replied by Sekhem from Florida on 02/24/2018
Reading this almost made me cry, hearing the death sentence from doctors is so disheartening. seeing this, and hearing something so Vile from doctors make you think the world is completely mad.How is your mother doing in 2018 if you dont mind telling us? also Did she remember anything from when she actually had the pathology of alzheimers? was she in there experiencing everything but not able to control it? or is she completely unaware of the things that were going on?
Replied by Sekhem from Fl on 03/01/2018
Could you explain how she was erratic emotionally? and at what point during this treatment did she overcome the erratic emotional behavior, it hasn't been a week yet with my mother, But I have her on the same treatment, and her behavior....Seemingly a paranoid schizophrenic type behavior at times is very taxing, if you could just give me a timeline to when she'll be over that, It would be so appreciated.Replied by Sekhem from Fl on 05/09/2018
Earth Clinic, is it possible that you could please try and reach KH for an update somehow please....this is unprecedented stuff here.Replied by Art from California on 05/15/2018
In reply to Sekhem (Fl),Although niacinamide was excellent in the mouse studies, it was not effective in the human studies. Here is a link to the full human study.
On the other hand, certain fairly common probiotics were helpful in another human study for AD as mentioned here:
https://www.sciencedaily.com/releases/2016/11/161110162840.htm
This study is very interesting because it is a human study and positive results were seen in the relatively short 12 week study, which is pretty unheard of when it comes to AD!
Art
Replied by Rose from Texas on 07/29/2018
Many pharmacists are able to answer questions about drug / supplement interactions. In fact, they're more likely to have the answer than doctors are. Find a pharmacist you like, then ask!Replied by Jo from Loveland, Colorado on 10/05/2020
Niacinamide:My mother had Alzheimer's and I have some difficulty remembering things, especially names. What dose should I start taking for this? And any side effects with this over the counter medication?
Replied by Art from California on 10/05/2020
Jo,The niacinamide studies were done at University of California at Irvine. The initial mouse study showed excellent results with the mice. The follow on human study showed little, if any, effect and further studies were not done. Here are the links to both studies :
Mouse study done in 2008:
https://news.uci.edu/2008/11/05/vitamin-b3-reduces-alzheimers-symptoms-lesions/
Human study done in 2017 :
Niacinamide/nicotinamide are relatively safe. If you end up trying it and it doesn't work out for you, you can consider a combination of supplements that a 78 year old friend of mine used successfully to reverse her memory lapses and senior moments. I just posted an update to that post. Here is a link to it :
https://www.earthclinic.com/art-solbrig-protocol-for-memory-loss.html
Good luck!
Art
Replied by Orh from Ten Mile, Tn on 10/06/2020
JO,ORH here, go into EC archives and you see that Niacinamide works at 3500 mg per day. The human trial at U of Calif that Art keeps referring to was a joke. Read and you will see it only had a few people for 6 months. It was a cover up by Big Pharma. You can buy a month of Niacinamide for about $5. No cruise on that chump change. My ole Wi boss only took 1500 mg/day and was sharp as a tack when he died last month at age 95 from kidney failure. He took it for 12 years. The human tests was delayed many years after the mice test and was a farce. The procedure Art promotes my be the best in the west, but don't bad mouth Nicianamide based on the Irvin farce. Delaying the human test for nine years tells you something.
====ORH====
Replied by Orh from Ten Mile Tn on 10/07/2020
Ole PATOOTS, ORH here, I forgot to mention that both my ole boss and I contacted the U of Calif, Ervine, in '08 because they were excited about the mice findings, and they were anxious to get started on the human trials. When that did not happen, we contacted them again and they said there would be no human trials. Then 9 years later, they say they ran a trial. Read the trial, it is High School stuff for certain. Most know how I ams. The term the puts me in the top of a tall pine tree is...... "It was not double blind tested." Hey, nothing on EC is double blind tested, so why bother reading? Yet, we all have benefited from reading this site. Trouble times are coming....... so fill up your stores. Fall garden is up with kale, carrots, radish, mustard greens, collards, beets and onions. Apples are breaking the limbs down. All my friends knew that I predicted what we are now going through. Not Nostradamus, but a REDNECK that has been half way 'round the watermelon.=== ORH===
Replied by Diver Dan from Idaho on 10/09/2020
I agree. There is almost no correlation between mouse/rat studies or doses and humans. very different physiology. I don't know why we even do so much live testing anymore as we have adequate simulations available. Maybe it's to keep people employed while performing cruel and unnesccesary experiments.Replied by micmed from Los Angeles on 01/24/2026
Can you share the brand?
