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CH (PD, FL, USA) on 02/06/2009:
Histamine aggravated levothyroxine-induced cardiomyopathy in guinea pigs.
Hu HJ, Dai DZ, Shen YM.
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.
AIM: To study effects of histamine on cardiomyopathy.
METHODS: Cardiomyopathy model was developed in guinea pig by i.p. levothyroxine 0.5 mg.kg-1.d-1 for 10 d. Langendroff's hearts were perfused. ECG and contractile force were recorded. Histamine (5 micrograms) was given by intra-aortic injection. Histamine content of coronary venous effluent was determined fluorometrically.
RESULTS: Attack of histamine on cardiomyopathy was severer than that in normal hearts. Tachycardia was more prominent; atrioventricular conduction block occurred earlier; decrease in coronary flow was more marked. Uptakes of histamine were 37% in the model and 19% in the normal hearts (P < 0.01).
CONCLUSION: Histamine aggravated levothyroxine-cardiomyopathy.
Levothyroxine
Generic Name: levothyroxine (LEE voe thy ROX een)
Brand names: Levothroid, Levoxyl, Synthroid, Unithroid
Zhongguo Yao Li Xue Bao. 1997 Mar;18(2):159-60
I then wondered if my symptoms got worse because of the synthroid
Gina (lethbridge, Ab/canada) on 01/01/2009:
I had night sweats (soaked through 4-6 changes of p.j.s every night) insomnia, painfully cold hands and feet, severe heart palpitations ( heart would Stop for a moment, then race to catch up, would sometimes make me collapse) nightmares, insomnia, muscle pain, chronic fatigue, painful menstruation, anxiety, phlegm,phlegm, phlegm, chronic cough, nasal drip, pelvic pain, constipation, diarhea, nausea, skin rashes, dizziness, fogginess, an indescribable feeling of unwellness, low blood pressure, hypoglycemia... the list goes on and on....it was unbearable and no wonder it sounded like hypochondria. I urge anyone who has many symptoms that they can't seem to resolve to check out www.wilsonssyndrome.com. I stumbled upon it and it has saved my life. The remedy is liothyronine...a natural substance normally produced by your body. It is not easy to find a physician who will work with you on this, but try. I only take one capsule per day, as opposed to cycling on and off the medication like the website says. It made life worth living for me again.