Art (California) on 11/23/2021

There is one existing article written on EC regarding MDS and it gives a few supplement recommendations, but gives no reason for those recommendations. I agree on the curcumin mentioned in the article because MDS is considered a type of cancer and curcumin has shown benefit in multiple forms of cancer and it has anti inflammatory and antioxidative stress qualities which are generally at elevated levels when it comes to cancer. Studies have used 4 to 8 grams of curcumin and Bioperine or Piperine is noted for increasing the bioavailability of curcumin while having some anti cancer effects of its own. Studies use about 10 mg of piperine or Bioperine at the same time as curcumin to good effect.

MDS, as mentioned above has the potential to morph into leukemia and for the purpose of helping to prevent this as well as infections associated with MDS, colloidal silver (CS) seems like a reasonable choice to consider as it has shown benefit in fighting leukemia in some studies. When I have used CS for serious health issues, I have used 8 ounces of capped 20 ppm per day for one month only, and then as needed to help fight any infections that may come along.

Melatonin has shown anti cancer effects, antioxidative stress effects, anti inflammatory effects, apoptotic effects (cancer cells), anti angiogenesis effects, synergy with radio therapy, synergy with chemotherapy, bone marrow protective effects and bone marrow mesenchymal stem cell protective effects. Something else to consider is that melatonin production significantly declines with age and cancer is considered an age related disease. So melatonin seems like it may have benefits making it worthy of consideration and given its excellent safety profile, even more so.

Some people have a feeling of next day tiredness from taking melatonin orally.

Melatonin using a topical application (15 drops) to the scalp, twice a day. Mix at the rate of 3/4 teaspoon melatonin powder per ounce of Everclear 60%. Topical application is thought to not have as much of a melatonin hangover effect in some people. I am currently using a similar mix, but I don't get the melatonin hangover, so I do not know how true this idea of helping to prevent next-day tiredness is for topical application.

The reason for topical application to the scalp is because the hair follicles have been found to offer good absorption and bioavailability.

N Acetyl Cysteine (NAC) has shown synergy with melatonin and has also shown the ability to reduce the oxidative stress generated by colloidal silver in studies. It is also a potent antioxidant. NAC at 1200 mg a day in a divided dose of 600 mg and 600 mg.

Fish oil at 4 grams per day. Vitamin C at 2 grams per day in a divided dose of 1 gram and 1 gram. Vitamin D 10,000 IU per day. Vitamin B-50 twice a day. These have all shown benefits in helping to improve the gut microbiome.

Based on the known effects of the above supplements, these supplements seem likely to act as an adjunctive treatment for MDS based on my understanding of the available studies. This is not a cure or stand-alone treatment.

Anyone considering trying this combination of supplements should absolutely get your doctor's approval and supervision to make sure it will be safe for you and compatible with all of your medications. I am not a doctor and this information is not a substitute for a doctor, as MDS is a serious disease!

Art