Art (California) on 05/13/2023

https://www.sciencedirect.com/science/article/abs/pii/S0197018621001832?via=ihub

Here is a relevant quote from the study :

' We found that BA and BX led to a remarkable reduction in U-87MG cell viability in a concentration-dependent manner. We also found that boron compounds increased the total oxidative status and MDA levels along with the SOD and CAT enzyme activities and decreased total antioxidant capacity and GSH levels in U-87MG cells without inducing DNA damage. The cytokine levels of cancer cells were also altered. We verified the selectivity of the compounds using a normal cell line, HaCaT and found an exact opposite condition after treating HaCaT cells with BA and BX. BA applications were more effective than BX on U-87MG cell line in terms of increasing MDA levels, SOD and CAT enzyme activities, and decreasing Interleukin-1α, Interleukin-6 and Tumor necrosis factor- α (TNF- α) levels.

Especially, BA application was found more favorable because of its inhibitory effect on PIK3CA, PIK3R1, PTEN and RAF1 genes. In conclusion, our analysis indicated that boron compounds may be safe and promising for effective treatment of GB. '

So based on this study, Boric Acid appears to be more effective than Borax against Glioblastoma (brain cancer) cells although both showed anti-glioblastoma activity. Importantly, both showed more activity against the cancer cells than normal healthy cells. This is a problem often seen in chemotherapy where it is toxic to the cancer cells, but also too toxic to the normal cells resulting in unhealthful outcomes.

Like borax, boric acid is very inexpensive and readily available in what would be considered bulk amounts and some people prefer it to borax because it is more refined, whereas, borax is basically unrefined. Another reason why BA may be preferred over borax is because of the salt content of borax, which would be important for people who have to limit their salt intake.
For those who take boric acid (BA), they generally take a lower dose than would be needed for borax because BA has more boron in it than borax does. Where borax is approximately 11.34% boron, BA is approximately 17.48% boron.

In any case, I thought this is important information worth sharing with the EC community because Glioblastoma has an average survival time of 12 to 15 months after being diagnosed which gives a very good idea of how ineffective the current medical treatments are for this form of cancer. So BA seems worth considering if you have glioblastoma and seems worthy of mentioning with the other two supplements I discussed in the original article at the beginning of this page.

Art