Art (California) on 01/31/2025
https://pubmed.ncbi.nlm.nih.gov/39886794/
Here is a very relevant quote from the literature review :
' The neuroprotective, anti-inflammatory, and antioxidant qualities of melatonin, a hormone mostly produced by the pineal gland, have drawn interest as a possible treatment option for AD. This study looks at new evidence that suggests melatonin overexpression to be a promising therapy option for AD. Melatonin levels naturally decline with age and decrease more significantly in individuals with AD, worsening neurodegenerative processes. Melatonin has therapeutic potential as it inhibits Aβ formation, prevents amyloid fibril extension through structure-dependent interactions, and protects neurons from Aβ-induced toxicity. Melatonin promotes neurogenesis, which is decreased in AD, suggesting it may treat the disease's many pathologies. The review emphasizes the importance of melatonin's mechanisms of action, including its capacity to reduce neuroinflammation, regulate mitochondrial function, scavenge free radicals, and influence apoptotic pathways. '
As you can see melatonin offers potential to fight Alzheimer's disease at many of its known activity pathways suggesting that melatonin will be very useful in many anti Alzheimer's disease regimens. Another advantage of melatonin is that it has a proven very good safety profile and with the advent of Melatonin Gel (MG) a better potential delivery method of systemic melatonin that can last approximately 24 hours whereas oral melatonin is only active for about 5 hours.
Another advantage of melatonin is that it can be very effective at ameliorating the "Sundowning" effect of agitation that comes on in the later afternoon in in many people with AD. Here is a link that gives a detailed explanation of "Sundowning".
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/symptoms/sundowning
I have seen how effective melatonin can be for sundowning and it can be a real game changer for that AD symptom alone!
Art
Bethie (UK) on 09/07/2024
Lions mane is ever more popular...more and more scientific research trundling in to support its claims. While still not mainstream I can, fingers crossed, say it is helping my Mum who has a diagnoses of mild cognitive impairment/brain disease. At the moment she is taking 4 grams a day
Ella ( London) on 08/17/2024
The Western diet composed of seed oils, sugar and refined carbs (also fed to patients in care homes and hospitals) may initiate dementia. Intermittent fasting, low carb, low sugar diets may prevent and hypothetically reverse dementia.
Fasting induces ketosis which reduces beta amyloid plaques and tau -
Dr Paul Mason - Reversing Dementia With Diet - A 2021 Update -
https://m.youtube.com/watch?v=muAvJ1y64PA
Finally, regular consumption of small amounts of turmeric powder may reverse dementia symptoms -
https://nutritionfacts.org/blog/can-turmeric-help-with-alzheimers/
I hope the above links can help someone.
Art (California) on 07/19/2023
I was wondering if migraines might be a forewarning of future AD, and according to the following article, it definitely is with people who regularly have migraine headaches being three times more likely for men and 6 times more likely for women to get AD than non-migraine people :
Here are two very relevant quotes from this interesting article :
' A 2001 study examining the risk factors for Alzheimer’s disease found that men and women with a history of migraine were three times more likely to develop AD.5 Looking at women alone, the study found that they were almost 6 times more likely to develop AD.5 '
' Another study was conducted to determine if migraine was a risk factor for dementia subtypes; Alzheimer’s and vascular. The study found that a history of migraine was noted in 23.5% of participants with AD compared to 9.9% of cognitively intact participants.6 They also found that people with a history of migraine were three times more likely to have dementia than people without dementia.6 Similar to the previous study, they found that people with AD were four times more likely to have a history of migraine disease.6 Interestingly, when looking at the subtypes of dementia, they found no correlation with a history of migraine and vascular dementia.6 '
I tried to convince my friends to try alternative means of improving her situation, but my other friend, her husband, will not try any alternatives even though she is declining very rapidly. She is now so bad in just two years that she could not remember to take helpful supplements without someone giving them to her.
If you have migraines regularly, you are at increased risk for AD, especially if you are a woman. It may be worth taking steps early on to improve your chances against getting AD.
Art
Mel (North West River) on 01/16/2023
conya (jmst, ND) on 05/11/2022
We started MMS, plant food diet, herbs, lots of water, and vitamins. He was taken off all pills and communicated with us. We did lots of our own research. That was 7 years ago. It is worth it to research everything, the truth is out there.
A New Treatment For Alzheimer's Disease From Seaweed Art (California) on 03/22/2022
In China, they have been testing GV-971, which is derived from a specific form of seaweed that is abundant there, for many years for use as a treatment for AD. They have finished initial testing in China and GV-971 is now available there for people with AD. Currently, they are also doing additional testing in North America and Canada, but that testing is still ongoing. Here is a link to a description of GV-971 and what previous GV-971 studies have shown regarding its usefulness for AD :
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Sodium_Oligomannate_(GV-971).pdf
GV-971 has several methods of action, but interestingly, one of its main methods of action is manipulation of the gut microbiome to reduce neural inflammation and protect neurons, while reducing oxidative stress.
Interestingly they are just starting testing GV-971 for Parkinson's disease also as noted in this report :
This is really good news because the currently available drugs for AD are only marginally effective in mild to moderate AD and their usefulness can dwindle fairly quickly in some PD patients or offer no benefit in others. Add in the known side effects associated with one of the more common drugs in this class of drugs, Aricept, and you quickly start to realize the importance of GV-971. Here is a link to side effects seen in some Aricept users :
https://www.drugs.com/sfx/aricept-side-effects.html
It is worth noting that they are considering further studies at even higher dosing in the future to find out if higher dosing can cause further or better response in people with AD. As far as I am aware, this is the first new drug that has come available for AD in many years in the whole world. In the human trials so far for GV-971 at the currently prescribed dose, showed a safety profile similar to the placebo group. In the trials for GV-971, it showed clear and sustained benefit when compared to the placebo group from week four right through to the 32nd week or trial end.
They have not said when the US and Canadian studies will be completed, but as soon as they are, GV-971 may become a reality here once the FDA approves it. For now, China has already added it to their "National Drug Reimbursement List " (NDRL) and reduced the price by 60%. The original price was RMB 895 ($140.16 usd) and was lowered to RMB 296 ( $46.50 usd). Generally, the US pays more for pharmaceuticals, so it will likely be significantly more than these numbers when it comes available here.
Art
ORH (TEN MILE, TN) on 03/27/2021
HI U OLE PATOOTS DOIN, ORH here and I have another yawn to spin. Getting senile, so I may have told this tale before.
My Natural Doctor uses a Glutathione IV in his treatment for folks with dementia. He is cheap by comparison, but it is over $100 a pop. I first did this and then I went to compounding and inhaling with a nebulizer. I called a few months ago and my compounding guy said Big Pharma had the rules changed so you can now only get two weeks supply at a time. They are part of the carbol that is about to fall.... along with the demons in the DUMBS.
Since I's SJS, I researched and found an L-Glutathione Plus reduced product that I could mix with saline, nebulize, and keep my brain sharp enough to stay two steps ahead of D. You can find this product on the net and it is dirt cheap. It has the same sulfur smell as my compound stuff, so I feel good about it. I can only work about a couple of hours a day at the farm, but like Wildroot Cream Oil, a little dab will do you. I think I may be able to get our garden in again this year. Hooray, we will not have to go to the PIMA camps and get the vaccine. Maybe I get to live to see the end.
ATS ===ORH===
Adele McN (Aussieland) on 08/08/2019
Johann (Atlanta) on 03/07/2019
Janet (Starke, Fl) on 09/04/2018
Alzheimer's Disease and Probiotics Art (California ) on 04/12/2018
With the Baby Boomers now in the senior citizen range, the number of people with AD is expected to reach unprecedented proportions that could potentially bankrupt are medical system because of the tremendous costs involved in the care of AD patients. These costs will continue to rise over time.
Given the poor prognosis for AD patients in general with the currently available meds that are unable to stop the disease process, we need alternatives to act as adjunctive help to go along with the prescription meds.
On that note, the following study shows that a 12 week course of a specific probiotic treatment was able to improve some disease symptoms in the treated patients. What is good about this study is that it is an actual human study as opposed to a mouse or rat study because those models do not always equate to humans in a like manner. A good example of this was the niacinamide mouse study that was done at the University Of Irvine California that showed almost complete reversal of AD symptoms in the AD model mice. The results were so good that a human study was done shortly after the results from the mouse study were released. Unfortunately the human study showed only marginal benefit at best for people with AD.
Here is a link to the probiotic / AD study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105117/
Another great point to this study is that the positive results were seen in just 12 weeks! It makes you wonder if a longer study period would have produced even better results. Another great positive to this studies is that other health parameters were improved along with cognition!
Probiotics have a good safety profile, are readily available and the ones used in this study are not the exotic ones which are almost impossible to find when you search. This is great news for people living with this horrible disease that affects not only the patient, but their family, friends and caregivers negatively.
Art
Lynne (Texas) on 01/18/2018
My questions are:
1. To be most effective, what is the ratio of 99% pure DMSO/distilled water to apply topically & how should it be applied (cotton, spray, roller, etc...?)
2. What do I use to dilute the 99% pure DMSO gel & to what ratio?
3. What is the best way to mix the 99% pure DMSO liquid to take orally to make it palatable, especially for Alzheimer's patients?
I would appreciate all suggestions!
Thank you!
God Bless!
Re: Niacinamide for Alzheimer's Disease Art (California ) on 05/11/2017
If you want just niacinamide with no additives at all and you are going to open capsules to divide your doses, you can just order pure niacinamide bulk powder such as this which should be better and cheaper:
https://www.amazon.com/BulkSupplements-Vitamin-Niacinamide-Powder-grams/dp/B00GW2LXWO/ref=sr_1_fkmr0_1_a_it?ie=UTF8&qid=1494483459&sr=8-1-fkmr0&keywords=pure+bulk+niacinamide&th=1
For people who are planning to take multiple doses per day, as some people have reported doing for Alzheimer's Disease, here is a method that might make it easier to take.
Niacinamide is water soluble, so if you are willing to do the math, you could potentially figure the total dose you want to take per week and dissolve it into water, juice, a sports drink etc.. As a basic example, let's say you want to take a total of 1,000mg of niacinamide per day in 10 divided doses or 100 mg per dose.
You would multiply the 1,000 mg daily dose times 7 to get the weekly dose of 7,000mg. Take those 7,000 mg as weighed on a cheap digital scale and dissolve it into a liter of water, juice, gatorade etc. The liter needs to be divided into 70 equal doses of 14.285 ml or just under a half ounce and each dose should deliver approximately 100 mg of niacinamide. Measure out one dose and pour it into something like a shot glass.
Make a mark on the shot glass that is equal to 14.285 ml and this is where you will fill the shot glass to for each dose. You would take ten of these partial shots each day.
By the end of 7 days the bottle should be empty. There are a couple of variations on this, but it will be easier to drink this mix than take capsules all day long and you won't be getting all of the fillers and gelatin capsules.......just the niacinamide.
Art
Timh (Ky) on 07/24/2016
Hope this link works for further reading.
https://doctormurray.com/pqq-the-next-nutrient-superstar/
Robert Henry (Ten Mile, Tn.) on 05/29/2016
http://www.nytimes.com/2016/05/26/health/alzheimers-disease-infection.html?_r=0
http://stm.sciencemag.org/content/8/340/340ra72
The commenters on one article noted that the natural folks have known this for many years and the conversation went down hill from there. Now we are learning that the polio vaccine was developed using the Rhesus Monkey which had the cancer virus and the shot was given to 200 million Americans. That is the reason in 1900 only 1 in 100 got cancer. Now 1 in 3 do. As Pogo said, we have found the enemy and he is us. I can promise you that I will outlive you by growing my own food and not taking vaccine shots, nor antibiotics. Cancer has been solved using many protocols in the last 70 years. I am using 3 of these in my own case.
As I have stated in the past ........ follow my path and learn one way or the other. Also learned that the US has 8X the Alzheimer's that India does. What is the difference? Curcumin.
============ORH=======
Mama To Many (Tennessee, Usa) on 02/10/2016
We got to the living room. My kids had stringed instruments and started to play. They played some songs that I knew he loved and had been singing for more than half a century. Dad immediately perked up. He sang along, he smiled, he showed nostalgic recongnition. He even stood up and started "directing." We sang and sang and sang. He clearly enjoyed it. What was interesting is that he seemed mentally better after we had been singing. When I had arrived, I don't think he knew I was his daugther or even someone he knew. Later he was introducing me to someone as his daughter. He couldn't recal my name. I supplied it and he said, "Oh, yes, " and then he said my middle name.
I have seen music affect my babies. I have seen music help children learn to read. And I know it is powerful.
I wonder what would happen if my Dad had a lot more singing time each day.
The nursing home where he lives does work hard to cater to the needs of memory care patients. The movies they play are the oldies that most residents would rememember from younger days - lots of black and white movies, even. Every day during meal time they play "big band" music. I have often seen my dad begin to dance a little when he hears the music. He loved to dance as a younger man even taught ballroom dancing.
I know research is being done with regards to the elderly and music. I would love to understand it more. But meanwhile, I know that music helps the brain, even of those with Alzheimer's.
How to put this into practice? If you have a loved one with Alzheimer's, make a point of playing music they loved when they were younger. Sing with them, when you can. I don't think all music is equally helpful. Music is emotional - it evokes happiness, depression, anger, excitement, restlessness, peacefulness. So be mindful what the music you chose is going to promote.
I am also convinced that complex classical music does amazing things for the brain. If you do not know where to start with classical music, start with Bach. It will keep you busy for years. Play Bach for the elderly people you love. Play it for your babies and toddlers and children, too. In fact, play it for yourself. I think it is something from which everyone can benefit.
"To send light into the darkness of men's hearts, such is the duty of the artist." Robert Schumann (German composer from the 1800's).
Alzheimer's and Fungus Sweetorange (Larnaca, Cyprus) on 10/31/2015
http://www.ncbi.nlm.nih.gov/pubmed/17051898
Acetaldehyde is a toxin produced by fungus. The abstract for the above-linked study from 2006 states that, "In the presence of acetaldehyde, dopamine is converted into salsolinol, a neurotoxin involved in apoptosis of dopaminergic neurons." In other words, fungus produces a toxin which combines with dopamine to make a neurotoxin, which then causes the dopamine-making neurons to self-destruct (apoptosis is programmed cell death).
Some researchers call Alzheimer's "Type 3 diabetes", as the patients seem to have high glucose levels in their brains. It stands to reason that, in a high-sugar environment, fungi could thrive. Does anyone have thoughts on this?
Charity (Faithville, Us) on 01/29/2015
Clare (England) on 08/16/2014
I was resigned to feeling more and more ill as the years go by, and now my mental outlook has changed too. Whether this is because I have more energy I don't know but I suspect it is. I have got my PT bouncer from its home in a cupboard and bounce three times a day. This is the most amazing exercise and because my hips and knees ache I am being careful, but this ever increasing energy has me putting on my iPod and going mad on the rebounder while listening to a Trance track with a fast beat. I am feeling better every day. Rebounding is wonderful. The more you do the better you feel. Hips and knees are taking it well. I was getting a bit weak and wobbly on my legs which made me feel unsteady. That is nearly gone and I have only been using the rebounder for a matter of days. I forgot to say I started the flax seed oil, flax seeds and quark regime for a painful lumpy breast and that went fairly soon into the regime.
