Mix (Gauteng) on 10/19/2025

I am trying to make the Melatonin lotion for my dad, as you have very kindly suggested. Having difficulty getting the pure powdered melatonin in SA but am working on it, is there an interim recipe crushing 5/10 grams melatonin tablets till I can source it?

Thank you

Joyce (Lynnville, TN) on 10/19/2025

Art (California) on 10/19/2025

I am sorry to hear about your brother in law. The following link might be worth reading on his behalf regarding the combined use of melatonin and vitamin D alongside chemo and radiotherapy as both offer anticancer effects of their in multiple forms of cancer including osteosarcoma and offer some protective effects against some of the known side effects of both chemo and radiotherapy. :

https://pmc.ncbi.nlm.nih.gov/articles/PMC11575929/

Here is a relevant quote from the research paper :

' As regards the central discussion of the present review, VitD and melatonin supplementation exhibit efficacy against several types of cancer. Clinical trials on this combination are still limited but are valuable in improving the quality of life of cancer patients. Specifically, human studies involving osteosarcoma, as well as lip, oral cavity, pharynx, breast, head, neck, brain and lung cancers are examples of these improvements. VitD and melatonin also have radioprotective potential, which could improve the effectiveness of radiotherapy and protect patients from its side-effects. The use of synthetic radioprotective compounds is restricted due to the occurrence of undesirable health consequences, particularly when higher doses are required for maximum radioprotection. Considering the prevalent deficiencies of melatonin and VitD in modern societies, supplementing with both substances would be crucial, given that such deficiencies may exacerbate the adverse effects of radiotherapy (e.g., ionizing radiation) and chemotherapy. In this sense, further studies are warranted to determine optimal doses when these agents are used in combination. '

' In addition to reducing the growth of cancer cells and improving the life quality of patients, this combination may improve sleep quality providing an indirect benefit on the cancer mediated by the connections between sleep and the immune system (229).'

His doctor will have to determine dosing that will be compatible with the chemotherapy treatment.

Art

Art (California) on 10/18/2025

Some people tolerate melatonin very well, such as myself who has taken 132 mg a day of oral melatonin for over a year, but some people do not tolerate oral melatonin at even a low dose such as 5 mg/day. So it is better to start very low and work your dose up slowly to find out how well you tolerate oral melatonin.

There are studies that have used high dose melatonin, but going over 100 mg/day studies are far and few between. So you are essentially moving in uncharted territory in terms of studies supporting 116 mg/day. Start low and slow to be safe.

If you are trying to concentrate specifically on atherosclerosis, you might give some consideration to adding bromelain to your regimen.

I don't know what medications you are using or health issues that you have, so the above items will require your doctor's approval and supervision before starting them.

Art

Helen (California) on 10/18/2025

Rob (Kentucky) on 10/18/2025

Vicks inhalation for a head cold involves using hot steam, either from a bowl of hot water with added Vicks VapoRub or a dedicated Vicks steam inhaler, to help relieve congestion by thinning mucus. It's important to use hot water.

From the book: Town Journal, Vol. 33, p. 29, December 11,1926.

Head Colds relieved with VAPORS

Snuff a little Vicks well up the nose or melt in a cup of hot water and inhale. Medicated vapors reach the air passages direct. For other cold troubles rub Vicks on the throat and chest.

From the label of a Vicks Vapor jar 1950’s. (yea… I collect weird stuff)

If there is much MUCUS or PHLEGM in the air passages, or much irritation or COUGHING, melt a spoonful of Vicks VaporRub in a vaporizer or bowel of boiling water. Then inhale the steaming vapors. Every few hours put some VapoRub up nostrils and snuff well back. At bed time, massage on throat, chest, back and bottom of feet as with simple colds.

Note: I’ve wrote a Article about, DIY Old School Steam Inhaler Nebulizer

See Article here: https://www.instructables.com/DIY-Old-School-Steam-Inhaler-Nebulizer/

I remember as a kid back in the 1970’s, my country Grandmother (she was born in 1911) putting a “whistling” tea kettle on the stove and when it started to “whistle” she would set in front of it (about a foot 12”) and inhale the steam. I also remember her putting a spoonful of Vick’s Vapor-Rub into the water. As the kettle got hot, the salve would melt and release the medical oils into the steam. I don’t remember her ever use the kettle to make tea in so I’m sure it was for steaming only.

I have not seen anyone mention this use of a tea kettle on the internet. It’s always some company’s selling some fancy electric device or something like that.

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Elizabeth (DE) on 10/18/2025

Randall (Wyoming) on 10/18/2025

I weigh 255lbs and am dropping ( 6'4") but it looks like I need about 116mg per day.

Is there any danger at that level? AI isn't the expert but said that high doses could be dangerous. I have some atherosclerosis I am trying to clean up with a no oil diet ( yuck) and meaninful supplements.

Just thought I would ask.

Thanks,

Randall

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Drew (Missouri) on 10/18/2025

Art (California) on 10/18/2025

Yes, Avery went for another CT scan very recently and his current number is 4.0. Originally it was 4.5 and then it went down to 3.8 and is now 4.0, which is fairly close to what would be expected at his age.

When I talked to Avery about it, he said he was still taking the zinc, selenium and quercetin, but he had stopped using the melatonin lotion(ML) twice a day and was only using it irregularly. He said he will go back to applying it twice a day again.

Apparently the ML is one of the more potent components of this regimen.

The following animal research abstract tends to confirm that idea :

https://pubmed.ncbi.nlm.nih.gov/32329099/

Here is a very relevant quote from the abstract :

' Melatonin functions as an endogenous protective molecule in multiple vascular diseases, whereas its effects on thoracic aortic aneurysm and dissection (TAAD) and underlying mechanisms have not been reported. In this study, TAAD mouse model was successfully induced by β-aminopropionitrile fumarate (BAPN). We found that melatonin treatment remarkably prevented the deterioration of TAAD, evidenced by decreased incidence, ameliorated aneurysmal dilation and vascular stiffness, improved aortic morphology, and inhibited elastin degradation, macrophage infiltration, and matrix metalloproteinase expression. Moreover, melatonin blunted oxidative stress damage and vascular smooth muscle cell (VSMC) loss. Notably, BAPN induced a decrease in SIRT1 expression and activity of mouse aorta, whereas melatonin treatment reversed it. Further mechanistic study demonstrated that blocking SIRT1 signaling partially inhibited these beneficial effects of melatonin on TAAD. Additionally, the melatonin receptor was involved in this phenomenon. Our study is the first to report that melatonin exerts therapeutic effects against TAAD by reducing oxidative stress and VSMC loss via activation of SIRT1 signaling in a receptor-dependent manner, thus suggesting a novel therapeutic strategy for TAAD. '

The above mouse study clearly suggests that melatonin is quite useful for thoracic aortic aneurysm in a mouse model and Avery's results that the benefit may also apply to humans, but a human study is required to confirm this. Such a study is definitely warranted because cardiologist seem to agree that they can not shrink an aortic aneurysm without surgery and of course there is significant risk involved with that surgery.

So based solely on Avery's experience, he seems to have responded fairly well to this regimen and especially to the topical application of melatonin lotion over his aorta area on his front and back twice a day applied sparingly.

Art

Art (California) on 10/18/2025

Hydrocodone does nothing for me either and it causes constipation in many people.

If ibuprofen is helpful for the pain, I think you will like the naproxen lotion and it should be useful post TKR also. Make a shot glass up of the naproxen lotion or use ibuprofen soft gels if you prefer, but either way this lotion is easier on your body. Some people find a slightly better effect from Naproxen over Ibuprofen.

Art

Stephanie (FL) on 10/18/2025

Mona (Anywhere) on 10/18/2025

Mona (Anywhere) on 10/18/2025

GertJr (Madison, AL) on 10/18/2025

Rob (Kentucky) on 10/18/2025

Both recipes are effective but… the Garlic Salve Recipe “Quick & Dirty Method” using coconut oil and a blender posted on 03/04/2023 is much easier to make.

Hope this helps…

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ironbutterfly (Israel) on 10/17/2025

Amanda (Florida) on 10/17/2025

amr2003 (california) on 10/17/2025

Lisa (FL) on 10/17/2025