I had Athletes' Foot between 2 toes that sit against each other. I had it off and on for years. It was hard to dry them after a shower, and when in a rush, I don't think I did it that well, and then sitting against each other, I would probably really have to, and sweating probably cause it also. I only applied cayenne in salt water one time, and it has been gone for years. Usually it has to stay in place for a while on skin surfaces, so I soak the gauze on a bandaid, but since my toes touch, I didn't have to.