Replied by Art from California on 11/29/2025

Applying melatonin lotion and mag oil simultaneously twice a day will help protect the cartilage and regenerate it while both offering some pain relief.

Here is a link to a typical magnesium lotion product :

https://www.amazon.com/Magnesium-Unscented-Relaxation-Overworked-Zechstein/dp/B09PVMTM9W/ref=sr_1_7?crid=3DKLMJP1OLTEL&dib=eyJ2IjoiMSJ9.YMWNpvMRDQYMfcpNKhH514Q0EkBw2Dxe7j44jU6_3grwXS4AL5Al8rwSl0BUtAq4hzPzPgcAJW_6OBIQ0lmPFk1m4nHxfFI71ndDM-NcKP6L-mGFI51w_WW6Uzf5bhxfU5Mdo8uc9_kgUAhOzjgpt4GATpK53iuJ2IoJDTTMRrDfPDMdUlJm36E34QFw6UMxkSb7ba3Bls7MG0w-Gr9pI2UTaAkXv2tyEPl0gK4n_-YSgbSEpgz2W68xFEi292R-ruJZN_7F3kjXuk9WXExbsz5rreWmDqE2YEX2ebpiddQ.nQ5wHPgTM9NSHLIZB1OO_aZbWwJqFryyxVH0YJYw9_Y&dib_tag=se&keywords=magnesium+lotion&qid=1764450095&sprefix=magnesium+lotion+,aps,171&sr=8-7&th=1

Here is a link that describes how to make melatonin lotion :

https://www.earthclinic.com/supplements/melatonin-lotion.html

It is worth noting that melatonin has more proven science for protection and repair of cartilage, but both are useful for this purpose as discussed in the following study :

https://www.sciencedirect.com/science/article/abs/pii/S1568163722000770#:~:text=Notably, melatonin has been associated, its potential anti-arthritic effects.

Here is a relevant quote from the link :

' Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and subchondral bone remodeling, is a common joint degenerative disease worldwide. OA pathogenesis is regulated by multiple predisposing factors, including imbalanced matrix metabolism, aberrant inflammatory response, and excessive oxidative stress. Moreover, melatonin has been implicated in development of several degenerative disorders owing to its potent biological functions. With regards to OA, melatonin reportedly promotes synthesis of cartilage matrix, inhibition of chondrocyte apoptosis, attenuation of inflammatory response, and suppression of matrix degradation by regulating the TGF-β, MAPK, or NF-κB signaling pathways. Notably, melatonin has been associated with amelioration of oxidative damage by restoring the OA-impaired intracellular antioxidant defense system in articular cartilage. '

Art