Mike (New York City, New York) on 02/09/2009
Replied By Robert (Manhattan, New York) on 02/10/2009
Replied By Brad (Owensboro, Ky) on 01/14/2012
Replied By Timh (Louisville, Usa) on 01/16/2012
Replied By Gord235 (Vancouver, British Columbia) on 10/04/2017
Replied By Gord235 (Vancouver, British Columbia) on 10/10/2017
I also take N-Acetyl-L-Carnite 1500mg/day and Calcium/Magnesium 2X 133/167mg/day.
This protocol has eliminated 90% of the pain and I believe it is the ALA that is helping the most. Best wishes and good luck to all in their search for relief.
Replied By Rosy Giana (A) on 10/29/2017
Replied By Soazburrolady (Az) on 10/30/2017
It was so interesting to read your information regarding ALA and the connection to depletion of Vitamin B.
About 4 months ago, I quite literally woke up with symptoms of Peripheral Neuropathy - numbness, tingling, weakness in feet, lower legs, hands, and forearms. It was particularly alarming to me as my mother had PN so severe that she needed a walker to ambulate.
After reading the info on Earth Clinic (my first go to! ) and some other sites, I did what I always do - which is use the "shotgun approach". I started on B complex, benfotiamine, niacinamide, sunflower lecithin, passion flower, evening primrose oil, and St John's wort. I also increased my B6, B12, and ....ALA. I have experienced such a lessening of symptoms - many days are symptom free, that I am reluctant to change the regimen. However, I will surely research a bit more on the ALA. I do think the benfotiamine has been really beneficial. I initially took a B1, but after more research, was convinced that benfotiamine is a better choice. Thanks for posting!
Replied By Gord235 (Vancouver, British Columbia) on 11/07/2017
Replied By Art (California ) on 11/08/2017
Art
Replied By Lily (Kelowna) on 03/24/2021
You may want to consider taking METHYLCOBLAMINE Vit.B12, sublingually. The type of B12 you take & how it is delivered to your system makes a large difference.
Replied By Clatterbuck (Beltsville, Md) on 07/10/2021
I urge caution when taking methylcobalamin. I have pernicious anemia and receive monthly shots from my doctor. I tried some oral methylcobalamin and it made me feel really awful. I felt anxious, irritable, and had horrible insomnia. Fortunately these side effects only lasted for 24 hours. I'll never take methyl anything again.
Replied By Wyandotte (Canada) on 05/01/2022
I tend to agree with you. Not all "improvements" in supplements (or anything else) are necessarily better than old fashioned remedies.
Replied By Novella (Lyons, Colorado) on 07/21/2023
For those who, like myself, have the MTHFR genetic mutation, certain substances meet to be methylated. For me, B-12 is one of them, and so is folate. It would be wise for people to see what their genetic status is. One could be wasting money on supplements that do them no good. I now use methylcobalamin and methyl folate.
Replied By Gord235 (Vancouver, British Columbia) on 12/14/2017
Sorry, I meant to say B12 - 10,000mcg not mg.
Replied By Gord235 (Vancouver, British Columbia) on 01/01/2018
Since my last post I have learned that taking antibiotics can lower B12 levels and that a B12 insufficiency can be the cause of peripheral neuropathy in up to 7% of cases. I had surgery recently and was on antibiotics for two weeks. This may account for the dramatic improvement I experienced once I started taking a B12 supplement.
As a result of this new information I have returned to my regimen of taking B1- 2X100mg/daily, B6 - 2X100mg/daily, B12 - 2X5000mcg/daily as well as ALA - 4X200mg/daily and Serrapeptase - 10X120,000SU/daily. Although not completely rid of symptoms the frequency and intensity of pain has been reduced by 90%. I anticipate that I will eventually be able to reduce the number of things I am taking but feel certain that the B12 will be the last thing to go as it has been the only thing to give me overnight relief. I wish everyone well on their search for a cure.
Replied By Gord235 (Vancouver, British Columbia) on 04/10/2018
Replied By Gord235 (Vancouver, British Columbia) on 04/23/2018