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ariley (USA) on 06/13/2026
5 out of 5 stars

Prion Diseases

Prion diseases are rare, fatal, neurodegenerative disorders/brain disorders caused by misfolded proteins that damage the brain, with Creutzfeldt-Jakob disease (CJD) being the most common form in humans; always progress to death within months to years after symptoms begin.

Causation: beef infected with Bovine Spongiform Encephalopathy (Mad Cow Disease), infected tissues during surgeries or transplants and other.

Prions and amyloid proteins are not the same, but prions are a specific type of amyloid protein that can cause infectious diseases by inducing misfolding by binding to normal proteins of the same type and forcing them into an abnormal, disease-causing shape that resists breakdown, leading to toxic clumps in the brain. While amyloids can form in various organs and are linked to several diseases, prions specifically affect the brain and are associated with neurodegenerative disorder; they can also impact other organs. Prions do not contain DNA or RNA.

Infectious: Yes, prions can transmit their misfolded shape to normal proteins, causing disease. No, amyloids are not infectious; they are aggregates that can cause disease but do not propagate. Prions: They are a subclass of amyloids all prions are amyloids, not all amyloids are prions

Internet search questions for further reading.

prions and amyloid proteins the same, phytochemicals that show prion-inhibiting activity, antiprion herbs/phytochemicals

Prion diseases include Creutzfeldt-Jakob disease (CJD), variant CJD, kuru, and Gerstmann-Sträussler-Scheinker disease. Amyloid proteins are associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Saliva tests are more effective than urine tests for detecting prions. I would think frequent testing would be required; for their are still unknowns about dosages for anti-prion phytochemicals.

Across diverse assays, particularly strong anti-prion phenolics include anthocyanins (Oenin, Myrtillin), chlorogenic/neochlorogenic acids, carnosic acid/carnosol, ellagic acid, pentagalloylglucose, EGCG and related catechol-type flavonoids, rosmarinic acid, myricetin, and punicalagin. Some show multi-step effects (blocking conversion, disaggregating fibrils, and reducing PrP^Sc in cells), but there is no single standardized potency ranking yet, and most data remain preclinical. Skullcap American and Chinese.

This is one disease you “DO NOT” want to treat yourself. Seek out Naturopathic Doctor, Functional Medicine Doctor or similar.

Amyloidosis coming in Part ll How to heal!

REPLY   3      

Replied By ariley (USA) on 06/15/2026

Prion Disease Part II Amyloidosis in prion diseases, amyloidosis is characterized by the accumulation of fibrils, which are aggregates of misfolded proteins. These fibrils can cluster together to form plaques, which occur in various neurodegenerative conditions. Medicinal herbs with anti-amyloid, anti-aggregative, or anti-fibrillation effects in the brain *Bacopa monnieri, Garlic, EGCG (Matcha has highest EGCg) luteolin, myricetin, silibinin. *Plaques turmeric/curcumin, Ginkgo, Salvia, Ashwagandha. *Curcumin from turmeric and rosemary, which contains carnosic acid, have shown potential in decreasing amyloid plaques and improving cognitive function. *Curcumin (from turmeric) and cinnamon have shown potential in reducing brain plaques and have shown neuroprotective properties. Internet search: medicinal herbs with anti-amyloid, anti-aggregative, or anti-fibrillation effects in the brain. Acetylcholinesterase inhibitors (AChEIs) are chemicals that block the enzyme acetylcholinesterase, preventing it from breaking down the neurotransmitter acetylcholine. In prion diseases, acetylcholine levels can drop significantly. This reduction is linked to the brain damage caused by the accumulation of misfolded proteins. Carnosic Acid and Carnosol: These compounds from rosemary have shown antioxidant and neuroprotective effects, found to have antiprion properties in prion disease contexts. Rosemary contains compounds that may inhibit the breakdown of acetylcholine along with other herbs. Internet search for more info: Carnosic Acid and Carnosol in Rosemary and Prion Disease Acetylcholine is a neurotransmitter essential for memory formation. Internet search: does acetylcholine levels drop in prions diseases. Tumeric, EGCg, Skullcap (American/Chinese) and Rosemary are all antiprion herbs. This is just my opinion with no science backing. If one would take smaller does of each. Tumeric with Bioperine 250 mg 3 times daily, EGCg 250 mg 2-3 times daily, Skullcap 250 mg of each American and Chinese 2-3 times daily and Rosemary 250 mg 2-3 times daily. All with a carrier herb like Ginger 100 to 200 mg. This would be spread though out the day taken every 2-3 hours. For example you buy both kinds of Skullcap get blank vege capsules and make your own dosage of 250 mg of each Skullcap and 100mg of Ginger and the same for the rest of herbs listed. Prions are resilient and need constant inhibitors. This would be a discussion with your Naturopathic Doctor. Have saliva test every 3-4 weeks to check prion levels to see if changes need to be made in regimen. Vitamin A through Zinc are imperative to have at functioning levels. Some may need to be taken at higher levels. ex. Vit. E, D3, Omega 3's and Choline (Sunflower Lecithin) more. Having nutrient levels checked would be essential. Antioxidants should be taken in a variety. Glutathione: deficiency in Prions Vitamin C, Vitamin E,, Coenzyme Q10, Alpha-lipoic acid, Resveratrol, and Quercetin and more on website: https://wellintruth.com/a-list-of-antioxidants/ Prion cells are not seen as a foreign body to activate immune response. Prions do cause inflammation which activates histamine. Quercetin with Bromelain lowers histamine and acts as antioxidant. Oxidative stress contributes to cell death in prion diseases by promoting iron-dependent ferroptosis. Ferroptosis can be inhibited by lipophilic radical trapping antioxidants such as ferrostatin-1, liproxstatin-1, and vitamin E, as well as by iron chelators like desferrioxamine (DFO). These inhibitors help prevent lipid peroxidation, which is crucial in the ferroptosis process. Prevent lipid peroxidation, a damaging reaction that can lead to cell death and various diseases. Lipophilic Antioxidants: Vitamin E, Carotenoids Metal Chelation: Managing metal ion levels will reduce oxidative stress, as metals like Iron, Copper, Manganese can exacerbate oxidative damage. Gut health is very important, brain/gut axis, kill off bacteria and parasites along with the biofilm they create, repair gut lining and feed it pre and pro-biotics. Treat as (leaky gut syndrome). Https://www.harvestheal.com/protocols/anti-prion-diet Findings are found in animal studies and should be discussed with Naturopathic Doctor or similar. Do Not try to treat yourself. Prions are tenacious, replicating Proteins.
REPLY   5      

Replied By ariley (USA) on 09/10/2026

Prions Disease Part III

The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases are poorly understood.

We show that abnormal autophagy activation and neuronal demise is due to severe, neuron-specific, nicotinamide adenine dinucleotide (NAD(+)) depletion.

Variety of NAD+ supplements on Amazon!

https://www.researchgate.net/publication/272185083_Neuronal_death_induced_by_misfolded_prion_protein_is_due_to_NAD_depletion_and_can_be_relieved_in_vitro_and_in_vivo_by_NAD_replenishment

Replied By Christine (Atlanta) on 09/08/2026

Please send part 2 asap. My mother has caa. Already experiencing dementia like symptoms. I want to try coconut oil but concerns about oil buildup
REPLY         

Replied By ariley (USA) on 09/09/2026

Christine,

scroll down one more article. Proteolytic enzymes.

Wish you the best!

Replied By Bill (Philippines) on 09/12/2026

Hi ariley...It's certainly true that prion diseases like Altzheimers, Parkinson's and Creutzfeldt-Jakob disease(CJD) are currently incurable by allopathic medicine and I would also wholeheartedly agree with you that the accompanying neuronal demise can be caused by NAD+ and coenzyme Q10 depletion.

To save time, here are some useful tips on how to alternatively treat prion diseases involving misfolded tau and amyloid beta proteins. Here's what I would personaly use to treat diseases relating to prion disease:

1. Methylene Blue(MB) - Through my own research I have found that MB is the only nutraceutical with the ability to actually destroy prions in the body. Also be aware that that although MB in its pro-oxidant form can indeed neutralize and eliminate prions, it cannot really fix the neuronal damage that has already been caused by prions disease. See links below:

Methylene blue and Alzheimer's disease https://www.sciencedirect.com/science/article/abs/pii/S0006295209003359

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein
https://www.sciencedirect.com/science/article/pii/S0925443912002141

2. Coconut oil. There are several coconut research reports and many case histories describing describing successful remission from Altzheimers Disease. See below:

Peer Reviewed Coconut oil Research
https://coconutoil.com/peer_reviewed/

Other Coconut Oil Research(not peer reviewed)
https://coconutoil.com/coconut-oil-research-alzheimers/

3. Niacin/Niacinamide. And the easiest way to increases NAD+ stores in the body would be to supplement high dose niacin or niacinamde(3gms per day directly after meals). Abraham Hoffer, an orthomolecular psychiatric researcher) has some interesting things to say about taking high dose niacin/niacinamide here:

Therapeutic potential of niacin in Alzheimer's disease
https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.040679

4. Lithium Orotate(LO). Dr Hans Nieper is quite famous and well known for creating a whole range of unique, alkaline mineral formulas. I recommend LO because the brain, in old age, always shrinks in size and there is no reasonable scientific explanation for this brain size reduction other than "It's just old age that cause the brain to shrink, right?". Wrong! If you take LO every day, this will actually stimulate brain growth. So, according to my way of thinking, LO therefore stimulates the proper use of protein for brain growth. Also please remember that tau and amyloid beta are forms of protein in the brain!

I've been taking all the above supplements fairly regularly to keep my own brain in top health. Notably, all the above nutrients are also capable of penetrating the blood brain barrier.

I must also mention that mid-2024 I started forgetting things. Simple words, mainly places, names etc. As a 76 yo man, this was quite worrying for me. The supplements that made the most difference for me are all the supplements mentioned above. My memory is back to normal now.

Here are my preventative dosages:

Methylene Blue: Between 10 and 30 drops of MB in water taken once or twice a day depending on the coming stress levels that day. MB dosage is difficult to advise because people have different sensitivity to MB. So my advice to you is to start low and increase your MB drop dosage until your brain "wakes up" -- and that is your dosage.

Coconut Oil(CO): As a preventative take tablespoons of CO per day directly after a meal. If you have Altzheimers/Parkinsons then take 3 tablespoons CO a day directly after meals.

Niacin/Niacinamide: As a preventative -- 500 mgs per day taken after a meal. For Altzheimers/Parkinsons you can take up to 3 gms of niacin/niacinamide per day in split doses. Take 1 gm niacin or niacinamide 3 times a day after meals.

Lithium Orotate(LO): As a preventative, 10 mgs LO per day taken outside meal times. For Altzheimers/Parkinsons you can take 20mgs or more LO in split dosages, it's up to you.

Replied By Bill (Philippines) on 09/13/2026

Just to clarify in my last post above:

For all dosage references concerning Methylene Blue, I was using 1% Methylene Blue!

With apologies

Replied By ariley (USA) on 09/13/2026

Bill,

Proteolytic enzymes can potentially dissolve tau tangles by breaking down the aggregated tau proteins that are associated with Alzheimer's disease. These enzymes work by cleaving the peptide bonds in proteins, which can help to reduce the accumulation of tau tangles in the brain. (If you can only take one capsule then it is just part of the equation).

Quercetin binding accelerates prion fibrillation into proteinase sensitive and loosely structured amyloids. Quercetin binding converts moPrP into protease-sensitive and non-cytotoxic fibrils.

https://www.semanticscholar.org/paper/Quercetin-binding-accelerates-prion-fibrillation-Yu-Jheng/279d14cb262cb602723775f58120fd74d6009748

I've also been looking at Collagen Peptides 1-6. Fibrils are made of collagen and weakened fibrils would potentially be more susceptible to Prion proliferation. Amyloid plaques would weaken fibrils and as plaques are dissolved they would need replenished with the structural support of Collagen Peptides and Vitamin C. Research is weak in this area, but it makes sense.

Thank you for the excellent knowledge. You and Art along with many others on this site do a great justice in helping others!!! Take care of yourself.