Art (California) on 01/02/2025

https://www.mdpi.com/2227-9059/12/8/1655#:~:text=Conclusions: Nicotinamide holds promise as, safety concerns in glaucoma patients.

Here is a relevant quote from the comprehensive literature review :

' The literature review revealed the preclinical evidence supporting nicotinamide's neuroprotective effects on RGCs, the preservation of optic nerve integrity, and the modulation of glaucoma-associated neuroinflammation. Additionally, nicotinamide may exert IOP-lowering effects through its influence on ocular blood flow and aqueous humor dynamics. Conclusions: Nicotinamide holds promise as a novel therapeutic approach in glaucoma management, offering potential neuroprotective and IOP-lowering effects. '

RGC = Retinal Ganglion Cell IOP = Intraocular Pressure

The following link is to literature describing the safety of high dose nicotinamide :

https://pmc.ncbi.nlm.nih.gov/articles/PMC7277745/#:~:text=These studies assure safety in, minor and resolved upon termination.

Here is a very relevant quote from the literature link :

' Meanwhile, tolerance of doses near 1 g (or up to 3 g) of daily intake of NAM, even during long-term administration, has been demonstrated in many studies. Examples are the European Nicotinamide Diabetes Intervention Trial (ENDIT), where children were treated with 25–50 mg/kg a day for 5 years without reported adverse effects [20, 97] and a recent clinical study which showed that intake of 1.5 g NAM twice daily for 6 months was safe in elderlies [NCT00580931]. These studies assure safety in the current wide-spread practice of long-term dietary intake of 500–1000 mg per day. Although headache, dizziness, and vomiting occurred in healthy humans when NAM at doses up to 6 g was ingested on an empty stomach [43], these adverse effects were minor and resolved upon termination.

Note that problems tended to start to occur in the area of 6 grams on an empty stomach. That is a huge dose for most supplements and I haven't seen studies suggesting that such high doses are useful and healthful.

In previous testing I have found Nicotinamide or Niacinamide to be very tolerable and noticed no apparent side effects at the dosages I tested. This is a useful addition to EC's list of glaucoma remedies.

Art

Replied By Art (California) on 01/05/2025

Hi NK,

To be clear on dosing, none of the referenced studies used nicotinamide, niacinamide or nicotinic acid(Niacin) directly in the eyes, but rather used human oral dosing or equivalent animal model dosing of Niacinamide in the 3 gram day dosing area for humans taken orally. This oral dosing area has been shown to be safe in previous studies.

The 1 hour of tingling and burning feeling you experienced does not sound safe in my opinion and is not reflective of the oral dosing used in the multiple studies which is known to be safe.

Art