Joey (NY) on 02/29/2024

Since one of the roles of statins is to "harden" existing plaque to prevent clots from breaking off, does Nattokinase work opposite of that in terms of it's power to dissolve plaque? Put another simple way, wondering if they're safe to take together or if they work against each other? Thank you.

Replied By Art (California) on 06/26/2024

Hi Sharon,

Regarding which statin for your husband to take, his doctor will make that decision for him as a prescription is required. Nattokinase, in more recent studies, have shown that 2000 mg of nattokinase is an ineffective dose for fighting atherosclerosis. The study I highlighted with over 1000 participants suggested that 10, 800 FU was useful for reducing atherosclerosis after 12 months. Here is a link to that article :

https://www.earthclinic.com/cures/high-dose-nattokinase-for-atherosclerosis.html

Here is a relevant quote from the study :

As shown in Table 5, no differences in NK efficacy were found between male and female participants, although changes in female participants were marginally greater, but were not statistically significant. We found that NK at 3, 600 FU dose was not effective in lowering lipids and suppressing atherosclerosis. Lipid levels and CCA-IMT and plaque size did not change after 12 months of NK consumption at that dose (Table 6).

Art

Replied By Jake (Chicago) on 06/27/2024

Art and Sharon,

I have been taking 12,000 NK now for the last 6 to 8 weeks. my blood pressure used to spike continually. I started Carditone and that brought it down quite substantially most of the time. I have now stopped Carditone as my blood pressure is now consistently -all the time- normal and lower - 110 to 120 over 70 or so just with the NK. No waiting anymore for the BP to normalize. Seems the Nk may be curing or at least improving the heart disease that runs in my family. (my father and his two younger brothers and the grandfather I am named after.) I am currently 80 years old.

Replied By Art (California) on 06/28/2024

Hi Jake and thank you for your feedback!

I'm very happy to hear that the high dose nattokinase is helping you significantly. In my case nattokinase had no apparent effect on my blood pressure, but it worked quite well for lowering total cholesterol, LDL, VLDL cholesterol and triglycerides while increasing my HDL cholesterol. I still maintain my blood pressure in a desirable range with Carditone.

Art

Replied By jake (chicago) on 06/29/2024

that's so interesting - your results versus mine - yet I would guess related. Aside from heart issues (family) my main issue is my kidney function - maybe that's somehow in the mix. I'm also doing well with high dose melatonin. Thanks for all your help.

Replied By Art (California) on 06/29/2024

Hi Jake,

The difference may lie in the dose you are using which is greater than the study dosage, while the dose I am taking is slightly less than the study dosage. I I haven't seen any human studies using 12, 000 FU.

Just a quick mention, a bioavailable form of magnesium such as magnesium glycinate that delivers enough actual magnesium not just magnesium glycinate to reach the RDA should be beneficial for the heart and kidneys while helping to reduce vascular calcifications.

Art

Replied By Art (California) on 10/29/2026

Hi Denise,

There must be some confusion here. I take the supplement Carditone to lower my blood pressure very well. The recommended dose is 1 tablet per night. One known and important side effect in some people is sinus congestion, which if it happens may make Carditone unusable for some people. I've been taking it for years and have not experienced the congestion issue, but I am aware of three people who have experienced this issue.

I discuss Carditone and high blood pressure here :

https://www.earthclinic.com/cures/high-blood-pressure-carditone.html

It works significantly better than the hypertension medication my doctor prescribed for me.

I take 10000 + FU's of Nattokinase to significantly lower my cholesterol and to try and reduce atherosclerosis, per the study I referenced in my original post on nattokinase which used 10800 FU's/day. I'm not positive on the exact dose I am getting, because the supplement I am currently using has shown not to be exactly what is listed on the label by an independent third party, but I believe I am taking 10000 + FU's/day. I have never noticed that nattokinase lowered my blood pressure, so I'm not sure why you said that.

Art

 

Replied By Denise (Michigan) on 10/30/2026

Thank you for explaining that to me. I will start natto mk2 and grape seed. What is the best brand of grape seed? I have doctors Best natto

thanks you

Replied By Art (California) on 10/31/2026

Hi Denise,

I think Doctor's Best Nattokinase is considered to be a good product.

For Grape Seed Extract I have used several over the years, but have settled on Carlyle Standardized Grape Seed Extract 24, 000 mg at 1200mg per day or 3 capsules. I noticed they also have another that says 4, 000 mg on the front label, but I don't use that one.

I take the recommended dosage on the back label of 3 capsules that are 400 mg each or 1200 mg per day.

Art