Art (California) on 09/09/2023
Berberine
The supplement I forgot is Berberine, which has, in recent studies, suggested benefit for bone regeneration in osteoporosis as discussed in the following link :
https://www.sciencedirect.com/science/article/abs/pii/S0378874121004761?via=ihub
Here is a relevant quote from the review :
- ' Berberine has a long history of medicinal use to treat various diseases including bone disease in China. Recent studies have defined its function in promoting bone regeneration and great potential in developing new drugs. '
Berberine is generally found in 500 mg capsules and is often used at 1000 to 1500 mg/day in divided doses.
Selenium
The second supplement is Selenium and selenium has shown that higher levels in the body are associated with improved bone mineral density (BMD) and lower levels of selenium are associated with increased risk for osteoporosis as discussed here in this 2023 meta analysis of multiple studies. Selenium supplements are generally available in 200 mcg capsules and Selenomethionine is considered to be a good form :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322231/
Here is a relevant quote from the meta analysis :
' From 748 non-duplicate publications, 19 studies were included. We found a significantly positive association between dietary selenium intake (β = 0.04,95% confidence interval (CI) 0.00 to 0.07, p = 0.029) as well as serum selenium (β = 0.13,95% CI 0.00 to 0.26, p = 0.046) and BMD. Consistently, those with higher selenium intake had a lower risk of OP (OR = 0.47,95% CI 0.31 to 0.72, p = 0.001), and patients with OP had a significantly lower level of serum selenium than healthy controls (WMD = -2.01,95% CI -3.91 to -0.12, p = 0.037). High dietary selenium intake was associated with a lower risk of hip fracture (OR = 0.44,95% CI 0.37 to 0.52, p < 0.001). '
So the addition of these two supplements can potentially be additive to the original supplements and can offer alternate choices for a person who does not tolerate a supplement from the original list.
Here is the new complete list of supplements :
1. Magnesium
2. Vitamin K2
3. Strontium Citrate
4. Boron
5. Vitamin B6
6. Vitamin D
7. Berberine
8. Selenium
9. Melatonin
Art
Replied By RSW (OH) on 09/24/2023
I have been going around in circles for the past month or more, trying to focus and get an order ready for Amazon of the bone supplements you suggest. I have read and re-read the various articles, but have been unable to create a list. I was also thinking of adding silica to the list to aid in bone repair since I am warned at every Rheumatologist visit that my right hip is in bad shape and the rest aren't good, either. I have put off taking the daily injections of chemicals for bone density that the doctor wants me to take. I have been pre-occupied with finding some natural relief for this multi-site, multi kinds of Arthritis, but after 2 1/2 years of trying whatever I can think of or read about with little relief, I am actually considering taking Methotrexate, although I loathe the thought, and this will not address the poor bone density. If I am reading and interpreting your suggestions for bone density supplements correctly ( and with this monkey-mind, (no offense to monkeys), I can't focus nor remember much.) Here is what I have so far-
1) Magnesium 300 mg/day
2) K2 200 - 300, mcg's/ day, Menaquinone 7
3) Strontium Citrate 450 mg. (Not sure about a poster's comment about not taking this).
4) Boron 20 mg/day
5) B6 as P5P, 50mg/day
6) Vit D3
7) Berberine 500 mg capsule, 1000/day
8) Selenium Selenomethonine 200 mg.
9) Melatonin - for me, up to 30mg/night seems like a good number.
10) Silica - supposedly helps with bone repair - I was thinking of adding this.
I would like to send my order in soon so I can get started repairing these bones. Do you see anything that doesn't look right on the list or anything I have forgotten?
Thank you for putting this all together, Art, with the vast amount of research you have posted. I don't know how I ended up with these bones and arthritis, always being active, doing yoga and cleaning the house and working in the yard, but I am so grateful for this advice. Thank you so much! Take care!
Replied By Art (California) on 09/24/2023
Hi RSW,It's been a minute!
Your list looks good, but I would not start those all at once. I like the vitamin D which is generally well tolerated and similarly, magnesium in a more bioavailable form. Vitamin K2 is generally well tolerated also at that dose. Definitely the boron unless you are already taking borax for arthritis, in which case you are already getting the boron. Selenium is also generally well tolerated. If you are already taking melatonin at that dose range, great. I would consider adding Berberine and the others a little later if you tolerate the ones I mentioned above. Give it a year and let us know how you do.
Art
Replied By Art (California) on 09/24/2023
RSW,I forgot to mention that the boron may help with your arthritis.
Art
Replied By RSW (OH) on 09/27/2023
Family members remind me that I have had arthritis for 1.5 years, not 2.5 years. I think that is good news and hope to get my memory back if I can ever stop this and get back to no pain and swelling everywhere. Best wishes to all the wonderful people on this site, and thank you, Diedra for creating this site.
Replied By RSW (OH) on 09/25/2023
I also wanted to thank you for posting about not drinking large amounts of green tea. I had always thought it was so good for you, that you could drink as many cups as you wanted. Now I limit it to one cup per day, or less, and drink black or herbal tea instead. Good to know!
Replied By Lora (Arkansas) on 12/05/2023
- I read with glee of no calcium. I take magnesium glycinate 133 mg three or four times daily to control my fibromyalgia. I take 5-10k D3 and it has controlled my arthritis immensely. Is this the right magnesium?
I am a 78 yr old female and felt 42 until my PAD attacked beyond chelation and began stent surgery as posted earlier probably because of my love for ff, BLT and ice cream.
I am so thankful I found Earth Clinic and its common sense and researched support. I have a logical brain and the drs will never talk me into statins.
Sorry so many illnesses and questions. I hope I have made sense. I plan on living to at least 100 in good health.
Replied By Art (California) on 12/05/2023
Hi Lora,Magnesium glycinate is what I use and is considered to be one of the bioavailable forms of magnesium. Topical magnesium chloride spray is additive to the magnesium glycinate for fibromyalgia.
PAD is considered a form of atherosclerosis, so you may be interested in this:
https://www.earthclinic.com/cures/high-dose-nattokinase-for-atherosclerosis.html
Art
Replied By Art (California) on 04/16/2024
https://pubmed.ncbi.nlm.nih.gov/38618998/
Here is a relevant study quote :
' Notably, MLT significantly increased the production of short-chain fatty acids and decreased trimethylamine N-oxide-related metabolites. Importantly, MLT could modulate the dynamic balance of M1/M2 macrophages, reduce the serum levels of pro-inflammatory cytokines, and restore gut-barrier function. Taken together, our results highlighted the important roles of gut microbially derived MLT in OP progression via the "gut-bone" axis associated with SCFA metabolism, which may provide novel insight into the development of MLT as a promising drug for treating OP. '
Art