Art (California) on 03/29/2022

Here is a new study( March 2022) showing the efficacy of Citicoline at just 250 mg/day for Glaucoma :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907038/

Here is a relevant quote from the study :

>>> ' With oral citicoline treatment, the loss in the average RNFL is prevented in POAG patients in the short-term. Study data show that citicoline may have a significant impact on slowing glaucoma progression, which could have a potential neuroprotective effect.'<<<

In the following RCT (June 2020) it is shown that even eye drops utilizing Citicoline is effective for Glaucoma :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337116/

Here is a relevant quote from the study :

>>> ' Additional treatment with citicoline eyedrops to IOP-lowering treatment might reduce disease progression in patients with progressing glaucoma despite IOP ≤18 mm Hg. ' <<<

In this last comprehensive review (March 2021) the protective role of Citicoline against the effects of glaucoma related neurodegeneration are elucidated in greater detail :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003774/

Here is a relevant quote from the study :

>>> ' In addition to the evidences of an improvement of psychophysical, morphological, and electrophysiological outcomes, coming from small comparative randomized pilot clinical trials or larger not controlled before-after studies (performed in different ophthalmological neurodegenerative diseases, like OAG, AION, and DR), for the first time a reduction of the rate of visual field progression has been recently reported in OAG patients in a large randomized double-masked placebo-controlled clinical trial, thus further supporting the clinical use of citicoline. ' <<<

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Art

Replied By kittyelli (Niagara Falls NY.) on 04/08/2022

Hello Art, I love all the articles that you have written on different subjects. I have been taking Citicoline for a few months and would like to add the eye drops, but have only been able to find them in Spain. I don't know what the regulations in Spain are concerning medication, consequently been afraid to order them. Do you know if they are available in the States?? Thank you. Kitty.

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Replied By Art (California) on 04/09/2022

Hi kittyelli,

Sorry about that, those drops are intended for oral use so they will not work for use as eye drops. I could not find the Citicoline eye drops available in the US.

Art

Replied By MICHELE (Ontario) on 10/06/2022

EYE DROPS ARE AVAILABLE - also an oral solution and pill form.

Replied By Art (California) on 02/07/2024

You are very welcome, Lin!

Thank you for coming back to share your results with the community as glaucoma is the second leading cause of blindness in the world, so having a practical way of controlling it is very important!

On a related note and a bit of a warning, choline is noted for increasing TMA and TMAO, and citicoline is thought to possibly do the same, but to a lesser extent as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683073/

Here is a relevant quote :

' It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO). Epidemiological studies have suggested that choline supplementation may improve cognitive performance, and for this application citicoline may be safer and more efficacious. '

So a little bit of bad, but a lot of good with citicoline.

TMA/TMAO are not good for our health, especially heart health. Fortunately your citicoline dose is low, vitamin D supplementation reduces TMA/TMAO and vitamin D is also thought to help glaucoma as discussed in the following links :

Vitamin D Reduces TMA/TMAO

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558778/#:~:text=The present study provides novel, AS and the resulting CVD.

Here is a relevant quote from the study :

' The present study provides novel findings that vitamin D supplementation can reduce the levels of plasma TMA and TMAO through the regulation of gut microbiota composition and may serve as a novel method for the prevention of AS and the resulting CVD. '

Vitamin D Useful In Glaucoma

https://www.hindawi.com/journals/joph/2020/8071280/

A relevant quote from the review :

' Vitamin D3 has been shown to play a major role in reducing inflammation, modulating the immune response, and decreasing angiogenesis in the eye and in other organs. It has been suggested that, through its neuroprotective effect, vitamin D3 could be a protective factor for glaucoma and that vitamin D3 deficiency could explain glaucoma occurrence or severity in some patients. Other neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis have been similarly related to vitamin D3 deficiency. '

So given the known health benefits of vitamin D, it makes plenty of sense to use vitamin D in conjunction with citicoline for best effect in glaucoma and best health.

Art

Replied By Lin (New Mexico) on 02/07/2024

On my third capsule of CDP Citicoline (250mg/dose) and I feel like a new person. The first dose totally relieved eye pressure within an hour. I also researched into heat shock proteins and I feel there is finally some hope for a realistic cure. As it also protects against Alzheimers (over 70 here) I feel its an amazing win. Thank you for posting this.

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