Art (California) on 03/03/2021
This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :
https://www.cureus.com/articles/47653-relationship-between-melatonin-and-cardiovascular-disease
Here is a direct quote from the article that is interesting:
>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<
Art
Replied By Art (California) on 10/04/2022
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9000067/
Here are some relevant quotes from the study :
' This pilot study demonstrated that compared to placebo, melatonin administration was associated with better outcomes in AMI patients undergoing primary percutaneous coronary intervention. '
' At 2 years of follow-up, 13 (13.8%) patients suffered the primary endpoint (3 deaths and 10 readmissions due to heart failure), 3 patients in the melatonin group and 10 in the placebo group. '
' The hypothesis-generating analysis found a relation between treatment effect and ischemia time and the authors concluded that melatonin administration within 3 h of ischemia onset reduces myocardial infarct size by approximately 40%. '
' The results of this pilot study indicate that treatment with intravenous melatonin in patients with AMI undergoing primary percutaneous coronary intervention is associated with a reduced incidence of death or readmission due to heart failure. '
This is the first study that I have seen using melatonin in people that have just had a heart attack and the results are quite impressive! The attached graph clearly shows that melatonin significantly improved longer term survival with just one dose given within 3 hours after MC. What this study doesn't show is what would have happened had the patients continued to take melatonin for the full study length of 800 days beyond the single dose given at the hospital.
Art
Replied By Art (California) on 02/08/2023
This new animal study (January 2023) shows that melatonin works to reduce aortic wall thickness in the tested animals fed a high fat diet :Here is what the study concluded :
' The administration of HFD to Wistar rats led to pathomorphological and morphometric changes in their abdominal aorta, which constitute the main diagnostic criteria of endothelial dysfunction. Melatonin supplementation regressed vascular wall remodeling and restored its functional capacity. '
Aortic wall thickening is a common component of cardiovascular disease (CVD) and reducing that thickening and restoring capacity is a huge step in reversing CVD. So this study adds further corroboration to the value of melatonin in fighting CVD.
Art
Replied By Art (California) on 05/17/2023
While many studies show multiple methods by which melatonin helps prevent or treat cardiovascular disease, this study link below suggests that melatonin also helps reduce vascular calcifications :https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12631
This is a quote from the study :
' Our results indicate that MT can potentially be used in the therapy of vascular calcification and ageing by targeting exosomal miR-204/miR-211. '
If you are wondering why reducing vascular calcifications (VCs) is important, according to the following article, VCs can increase your risk for heart attack, stroke, dementia, renal insufficiency and inadequate blood supply to arms and legs :
https://share.upmc.com/2018/09/what-is-vascular-calcification/
Art
Replied By Frances (Cabarlah, Qld.) on 12/02/2023