Art (California) on 03/03/2021

This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :

https://www.cureus.com/articles/47653-relationship-between-melatonin-and-cardiovascular-disease

Here is a direct quote from the article that is interesting:

>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<

Art

Replied By Art (California) on 02/08/2023

This new animal study (January 2023) shows that melatonin works to reduce aortic wall thickness in the tested animals fed a high fat diet :

https://www.cureus.com/articles/128955-effects-of-melatonin-supplementation-on-the-aortic-wall-in-a-diet-induced-obesity-rat-model#!/

Here is what the study concluded :

' The administration of HFD to Wistar rats led to pathomorphological and morphometric changes in their abdominal aorta, which constitute the main diagnostic criteria of endothelial dysfunction. Melatonin supplementation regressed vascular wall remodeling and restored its functional capacity. '

Aortic wall thickening is a common component of cardiovascular disease (CVD) and reducing that thickening and restoring capacity is a huge step in reversing CVD. So this study adds further corroboration to the value of melatonin in fighting CVD.

Art

Replied By Art (California) on 05/17/2023

While many studies show multiple methods by which melatonin helps prevent or treat cardiovascular disease, this study link below suggests that melatonin also helps reduce vascular calcifications :

https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12631

This is a quote from the study :

' Our results indicate that MT can potentially be used in the therapy of vascular calcification and ageing by targeting exosomal miR-204/miR-211. '

If you are wondering why reducing vascular calcifications (VCs) is important, according to the following article, VCs can increase your risk for heart attack, stroke, dementia, renal insufficiency and inadequate blood supply to arms and legs :

https://share.upmc.com/2018/09/what-is-vascular-calcification/

Art

Replied By Randall (Wyoming) on 10/18/2025

Art, I am following your Nattokinase and grapeseed extract guidance and have ordered melatonin now.

I weigh 255lbs and am dropping ( 6'4") but it looks like I need about 116mg per day.

Is there any danger at that level? AI isn't the expert but said that high doses could be dangerous. I have some atherosclerosis I am trying to clean up with a no oil diet ( yuck) and meaninful supplements.

Just thought I would ask.

Thanks,

Randall

Replied By Art (California) on 10/18/2025

Hi Randall,

Some people tolerate melatonin very well, such as myself who has taken 132 mg a day of oral melatonin for over a year, but some people do not tolerate oral melatonin at even a low dose such as 5 mg/day. So it is better to start very low and work your dose up slowly to find out how well you tolerate oral melatonin.

There are studies that have used high dose melatonin, but going over 100 mg/day studies are far and few between. So you are essentially moving in uncharted territory in terms of studies supporting 116 mg/day. Start low and slow to be safe.

If you are trying to concentrate specifically on atherosclerosis, you might give some consideration to adding bromelain to your regimen.

I don't know what medications you are using or health issues that you have, so the above items will require your doctor's approval and supervision before starting them.

Art