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Art (California) on 05/10/2020
5 out of 5 stars

Let's discuss the bad first 😩😩😩 and the good second! Covid-19 was originally thought to zero in on the lungs and the ACE-2 receptors located there. More recently it has been found that C-19 is attracted to ACE-2 receptors in other areas of the body and the virus is now known to attack much more than the lungs! C-19 autopsied patients are showing that it is attacking the heart, kidneys, liver, lungs, brain, skin, endothelium and is causing blood clotting which is causing heart attacks and strokes in patients who are otherwise asymptomatic and not considered to be in the high risk groups. Yes, the virus is causing much more damage system wide than initially thought. C-19 is causing a 4 times increase in Kawasaki disease reports in New York. The disease is attacking the vascular system and causing very elevated oxidative stress levels as well as significantly elevated inflammation. It also seems to be causing significantly more problems in black people who are not necessarily in the at risk groups, but possibly should be. C-19 is causing heart attacks, strokes, heart damage, pneumonia, liver damage, lung damage, organ failure, Kawasaki or Kawasaki like disease, rash up to full body coverage, blood clotting in different areas of the body that can potentially result in the need for amputation, neuronal damage, intestinal issues and death and this is an incomplete list! Yes, this disease is very serious indeed, even for those not to be considered in the high risk groups. Many of the heart attack and stroke victims are much younger than these two conditions are generally associated with, with no previous symptoms and doctors are only finding out these patients have C-19 when they start working on them and see the damage that is known to be associated with C-19 and that is when they are tested and confirmed to have C-19. Yes, this is one f'd up disease that is considerably worse than initially thought and it seems like new troubling aspects of this disease are being discovered each week if not almost daily !!! Now let's discuss the good! 😂😂😂 The good news is that melatonin works against this disease process at multiple levels of disease progression and at every place in the body where the disease has been found because melatonin can readily penetrate body tissues (including its metabolites) and easily cross the BBB to express its very potent antioxidant and antiinflammatory effects as well as other positive effects. Melatonin is a protector of all major organs and is protective of endothelial cells as well as the skin. Melatonin has anti-clotting abilities. Melatonin has shown itself to "upregulate the gene expression" of some of the bodies own very potent antioxidants such as Catalase(CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) and this aspect of melatonin is very important because it is very likely that all of these natural antioxidant defense mechanisms of the body are being depleted very significantly trying to fight this disease because of the multiple areas of the body being affected simultaneously, so melatonin boosting their production can help to level the playing field giving the body more than a fighting chance to defeat this virus. Since it has been proven in autopsy that C-19 is attacking multiple areas of the body simultaneously, it is as though the body is fighting multiple diseases all at the same time!Never show up to a gang fight with just yourself! Melatonin's boosting of the body's potent antioxidant system is absolutely needed to deal with something worse than it would normally ever have to deal with in moderate and severe patients. Add to this melatonin's potent and broad antiinflammatory abilities and things are starting to look hopeful! To add a little more brightness to that light at the end of the tunnel, melatonin itself is a highly potent scavenger of Reactive Oxygen Species (ROS), Reactive Nitrogen Species(RNS), hydroxyl radicals, Hydrogen Peroxide(H2O2) and Peroxynitrite (ONOO). All of these radicals are thought to be highly active in C-19 and doing a lot of damage. One melatonin molecule can scavenge up to 10 oxygen radicals while many other antioxidants can only scavenge and neutralize one oxygen radical 1:1. Melatonin inhibits NADPH Oxidase which is a very bad player that ends up generating ROS in large amounts and damaging almost all cells in its path. Now let's add in the vitamin C that Dr. Neel is using alongside melatonin in his C-19 patients. Vitamin C is synergistic with the antioxidant and antiinflammatory aspects of melatonin! Together they are better than either one alone and vitamin C pales in comparison to the broad ranging effects that are melatonin, but adding it to melatonin makes melatonin more potent. That light at the end of the tunnel is looking brighter! 💡🔦💡🔦💡🔦💡 A couple of points I would like to make. Originally some people thought that inhalation of food grade hydrogen peroxide via a nebulizer or ultrasonic vaporizer would be sufficient to kill the virus and it likely will in the lungs if you use HP as early as possible, but HP is an oxidant and Catalase will come along and neutralize it soon enough, turning it into water and oxygen, which means HP will not have staying power and more importantly, it suggests that HP will never make it past the lungs to other areas of the body where the virus may be thriving. So I would not want to rely on HP alone. Though I am a believer and user of silver nanoparticles (AgNPs), although inhaled AgNPs are likely to have staying power in the lungs before being absorbed into the blood I do not believe that by itself it will be enough. It will require drinking the AgNPs also and that combination with melatonin and vitamin C, may just be what it will take to put this virus down as quickly as possible, in my opinion. Although I think melatonin and vitamin C may be sufficient, I think that the addition of AgNPs will speed the process considerably! Art
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Replied By Ragaa Shabib (Jordan) on 05/11/2020

What brands of nanoparticle silver are good ones?
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Replied By Art (California) on 05/12/2020

Ragaa Shabib, The only two products I have seen that appear to be AgNps or silver nanoparticles are MesoSilver and MediSilver : https://www.amazon.com/MediSILVER-AMBER-Traditional-Colloidal-Silver/dp/B00ADQ5VWS https://www.amazon.com/s?k=mesosilver&ref=nb_sb_noss_1 I'm not recommending either one, just saying they appear to be AgNPs. As far as I know, everything else is likely ionic silver as they are colorless unless you go to a chemical supplier who can probably get most anything you want, but probably at a higher price though. Art

Replied By Art (California) on 05/11/2020

I no sooner got this list above this post complete and posted last night and I read the following article that shows that Covid-19 is negatively affecting the eyes too! Just when I thought this disease couldn't get any worse, it does! https://www.medpagetoday.com/infectiousdisease/covid19/85752 Art
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Replied By Dave (California) on 05/11/2020

What would it take to get this to politicians?
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Replied By Art (California) on 05/11/2020

Dave, That is a really good question! I'm trying to spread the information around as much as possible about melatonin, but actually trying to get a politician to seriously look at and consider it is another story. What I have noticed is that the drugs that they are repurposing for use with Covid-19 patients are only marginally effective or not effective enough. Hydroxychloroquine is only marginally effective at best and Remdesivir, although touted by Fauci, is only marginally effective. This seems to be the case with most if not all of the drugs they are trying so far. It seems like more natural items like those presented here on EC are mostly ignored by scientists and the powers that be. The government is having to spend trillions of dollars to try and keep the economy going, but they don't seem interested in spending a few million dollars to trial supplements or vitamins of any kind. Our government seems so convoluted when it comes to Covid-19. Everyone seems to have their own agenda and alternatives, supplements, herbs and vitamins do not seem to be on anyone's agenda who might have the power to actually test them in patients. If I was in Fauci's or Trump's position, I would have a very small team of people scouring the internet everyday to find ideas that might sound promising and EC seems to be a very good place to start looking, but clearly that is not the case. They would rather pump their research dollars into drugs that are not really showing good results at all. Dr. Neel is, in one week, highly recommending that doctors use melatonin in their Covid-19 patients based on the very good safety profile of it, as well as a lot of research studies clearly suggesting that it is definitely worth trying and testing it. And then the very next week is already using it successfully in his patients. He's only been using it since the beginning of April and already has 14 patients on it. I think it is going to take doctors like him who are willing to suggest it to their patients. And if more doctors find similar results in their Covid-19 patients as Dr. Neel has, then the politicians will have no choice, but to start testing it in trials. In the meantime, we common folks are left to figure things out on our own! Art

Replied By Dimoune (Africa) on 05/11/2020

Art, If someone does not have access to melatonin, do you think drinking and nebulizing AgNP is a good alternative?
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Replied By Art (California) on 05/11/2020

Dimoune, Before I found out about melatonin for this purpose, my intent was to use the combination approach of inhaling and drinking with silver nanoparticles (AgNPs). The truth is that there is no clinical experience with AgNPs for Covid-19 or anything else, but the method of action seems likely to work, so I would have tried it right away myself and if I didn't think it was working or working well enough, I would have moved on to something else or added something else with the AgNPs just in case. Art