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Guenady (Nice, France) on 08/10/2008
0 out of 5 stars

For your accumulated information on adverse reactions to drugs, two of my dogs were prescribed ketoconazole for a yeast skin infection. One survived the treatment, the other died during treatment. Other than the skin infection (which was not life threatening), he had no health issues. I was not told before treatment that this medication is hepatotoxic and that it can kill, that it has been established by the manufacturer that there is a 1:10,000 risk of allergic reaction (with underreporting recognized). The vet was not aware (!) of the symptoms of allergic reaction, so when I reported them she did not stop the treatment (dark urine, extreme fatigue, skin turning black and peeling...). When I finally stopped the treatment myself, because my dog was just getting sicker and sicker (after 13 1/2 doses administered out of 30 prescribed) it was already too late. 4 days later he came down with hepititis and 34 days after starting the treatment he died (with bloody vomitting and bloody diahrrea). Although I reported all this, despite my distress) nothing was taken into consideration, everything was dismissed as being a coincidence, and I was given the classic excuse 'your dog was already sick and would have died anyway.' This is an outright lie, of course, and contradicts all the medical file of my dog. But try to get an adverse reaction taken into consideration when the 'authorities' don't want to take it into consideration! Of course there is underreporting! Normally I never give vet medicines to my animals, only homeopathy, but at the time I had no alternative therapy, as skin yeast infection is very difficult to treat. I have since gotten my second dog almost out of her condition, using probiotics and herb Robert and direct applications of hydrogen peroxide on the worst affected areas. My opinion of vets and the authorities that 'oversee' them, has descended to about 0. Would like to know if others have had bad experiences with ketoconazole.
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Replied By Cindy (Torrance, California) on 08/12/2008

I had a similar problem with Ketoconazole as my Shar Pei had a terrible case of yeast. I stopped the medication after his underbelly started spotting black. After scouring the internet I found the website nzymes.com. It took over 1 year to completely clear up the yeast using their protocol and only feeding him a protein diet (I still cook chicken and spinach for him). I recommend anyone who has a yeast problem with with pet to start them on this protocol.
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Replied By Jean (Desert Hills., Arizona) on 10/03/2008

I would like all pet owners to not give their dogs Ketoconazole for Yeast or Valley Fever. Against my best judgment I gave this to our dog for Valley Fever and he died 3 months later from a failed liver. This is one of the side effects. It is much better to go Natural and stick with this so your dog will have a better life. And by the way they have a cure in Tucson, Arizona at the University of Arizona, but this is another drug and would have to be checked out for side effects. Many states have Valley Fever now. The states are California, Nevada, New Mexico, Texas, Arizona, and Utah. This problem in in the dirt. Something needs to be done. This affects humans and animals and etc.

Please beware of what I am saying for the sake of your pet!!!

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Replied By Pamela (Austin, Texas) on 11/15/2008

My 8 year old standard poodle was prescribed ketoconazole to suppress a chronic yeast outbreak in his ears. His liver would not tolerate it. I pilled him once. He vomited bile. That was the end of that.
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Replied By Dana L. (Darlington, Sc) on 02/07/2010

My pekingese mix was prescribed Ketoconozole three days ago but after her third dose today (100 mgs 2x daily) I think I'm going to stop giving it to her. She has developed a nagging cough, which she has NEVER had before since she started taking this medicine. I'm worried that the long-term side effects will be much worse than this cough we're experiencing. I don't know what I'll do about the yeast infection in her ears but we'll just have to find something else!
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Replied By Lulu (England, Uk) on 11/25/2010

Just wondering if Ketoconazole Shampoo has the same effects as the medicine? I use the shampoo for treatment of scalp psoriosis and works well. After reading the items about Ketoconazole Im just not sure if I should use it on my dog? any thoughts would be much appreciated : )
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Replied By Steph (Kennedale, Tx) on 06/20/2011

An australian shepherd or border collie mix puppy we had taken had some kind of rash so we thought after a month of it not going away after using different shampoos we should take it to the vet. He was treated for ringworm. The vet had prescribed ketoconazole and after 5 days of giving the half tab every 12 hours we noticed he stopped eating. We were told to stop giving the medicine and to try giving boiled chicken and rice. The pup became very weak and fatigued and would not eat and just lay there. Deciding not to take him back to the vet who had prescribed this treatment which was made him worse than what he was originally, we let the dog peacefully go.

I would really think twice before giving dogs medicines and found out that most cases of ringworm can disappear on their own. I should have stuck with mother nature instead of trusting a licensed professional to assist with this matter of nature.

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Replied By Julie (Coventry, England) on 08/22/2011

ALL OWNERS OF COLLIE & SHEPHERD DOGS & CROSSES OF THESE BEWARE, THEY HAVE CARRY MDR1 GENE WHICH MEANS MULTI DRUG RESISTANT 1 GENE AND SHOULD NOT RECEIVE MEDICINES WITH IVERMECTIN /AVERMECTIN IN (FLEA TREATMENTS) NOR ERITHROMYCIN ANTIBIOTIC OR IMODIUM THESE DRUGS CAN BE FATAL. TELL ANYONE YOU KNOW WITH THESE BREEDS. PLEASE.
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Replied By Jeffersonhi (Mililani, Hi) on 12/27/2011

Our 15 year old New Zealand Light Golden Retriever was prescribed Ketaconazole on 12/10/2011 by our vet, who did a complete work-up on her since she hasn't been in to see the vet in two years. We were there just for a check-up which they "required" in order to refill our Rymadil prescription for her achy joints. They did a blood test, fecal sample exam, the works - and kept her in the small kennel cage all day long... Then charged us $480 for it all. We were gratified to hear from the vet that she's a strong dog for her age, and had a clear result from her blood and stool sample test.

We dutifully gave her the Ketaconazole twice a day... But stopped after she refused to eat anything. We went online and discovered this (and many other) threads documenting the terrible and awful reaction to Ketaconazole... And are worried sick. We are giving her Pedialite to get fluids into her (she licks the bowl clean), but don't want to give her food yet... Since she was vomiting everything we gave her earlier. It's been 12 hours since she last ate. We have no alternative but to take her back to our vet (who has otherwise been a good friend and shown kindness in every respect to our dog and us). We will be sure to print out this thread for his enlightenment on Ketaconazole.

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Replied By Cheryl (Stockton, Ca) on 01/08/2012

To the December 2011 poster - how is your dog doing?
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Replied By Carly (Raleigh, Nc) on 01/14/2012

My 10 year old Jack Russell began allergic reactions to, what we thought and were told by vets, flea bites. The itching and chewing to the point of seeping sores has driven him (and us) crazy for nearly 6 years. We spent ridiculous money on one remedy on top of another, injections, steroids... You name it. We became a stressed out, worn out, broke and vet-leary bunch embarrassed to be seen in public with our patchy smelly dog that appeared to be neglected and abused. Our dog was miserable and we were clinically depressed of the whole issue... And (can't believe I'm saying this) considered other options to relieve his suffering, and ours.

Then came the day when I was faced with what I thought were earmites and a severe ear infection. This was a first for my dog and I was confused because it didn't LOOK like earmites but was red, crusty and he was scratching it raw.

Finally, at my wits end, I was reading a homeopathic site and the article mentioned the smelly, itchy stench of a yeast infection in dogs. Frankly, never having had one, I was under the impression this was only a human and female ailment. WRONG! I began treating him immediately for a yeast infection. I started him on Blue Buffalo food (duck) and half a tab of acidophilus and filtered water. I rinsed out his ears with an earwash and bathed him in Nazirol (ketoconazole) shampoo every 2 days. I currently use only hydrosol for fleas and ticks.

My dog, in just over a week, has become a different animal. He is the dog we originally brought home. His eyes are clear and alert, he is energetic and keen and he sleeps like a rock, no scratching, no anxiety and we are sleeping disturbance free.

I am posting this because I can't even imagine giving ketoconazole orally. I am deeply disturbed that for so long and from so many of what were touted to be the best veterinarians in our area, not one of them suggested that Yeast might be the problem. I have decided to seek out a holistic Veterinarian because I no longer trust the expensive drug-pushing establishment.

Nutrition is a best weapon for many ailments. While I am in no way suggesting medicine has no place in treating animals, I will say that owners should be cautious.

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