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Susan (San Francisco, Ca) on 05/15/2013

I read somewhere that the Vitamin B12 molecule is too large to penetrate the skin. Does anyone know of a website that lists molecule sizes (I haven't been able to find one) of various things (obviously including Vit B12) and what will or will not be absorbed by the skin? I've been using DMSO with B12 in it and would like to know if I'm wasting my time by using it this way. Thanks so very much!
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Replied By Susan (San Francisco, Ca) on 05/15/2013

I did just find the following: DMSO will not carry anything with a molecular weight of over 1000. I also read that B12 has a molecular weight of 1,355. Is this 1,355 figure correct? Is it true that DMSO cannot carry anything higher than 1,000 correct? I've seen testimonials about the effectiveness of B12/DMSO (even the Dr. Mercola website seems to espouse it). Does anyone know if any of these figures are correct? Thanks again.
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Replied By Hannah (Leicestershire) on 12/04/2016

Hi, I can safely say that dmso with b12 works really well. I have loads of energy and high mood on a consistent level. Sublingual b12 also worked well though I feel the dmso b12 used transdermally is far more effective. I do take a high potency b complex aswell as they all work together.
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Replied By Clatterbuck (Beltsville, Md) on 06/24/2022

I have pernicious anemia and will need B12 shots for the rest of my life. There are several reasons why B12 may not be absorbed by a body, as we age our intestines are less able to absorb nutrients, use of PPIs inhibits absorption of vitamin B12, etc. The most important factor is B12 must combine with intrinsic factor (a protein produced in the stomach) in order to be used by the body. We produce much less intrinsic factor as we age. This is why anyone over the age of 50 should have their B12 levels checked.
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