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Tim (Long Island, New York) on 04/11/2008
5 out of 5 stars

The two main ingredients of a hangover are: 1) depletion of vitamins and 2) lack of restful sleep (even if you sleep 8 hours). This is what I do when I've had plenty, and it works every time to eliminate or at least minimize the effects. I take a B complex vitamin and/or a regular multivitamin and I take ONE Tylenol PM before I go to sleep. You'll wake up feeling good, without that tired, nervous feeling you get when you've really tied one on.
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Replied By Cheryl (Powell, Wyoming) on 07/12/2008

Please tell all your readers NOT to take any acetominiphine (Tylenol) products when drinking. It really stresses your liver even more than already stressed from the alcohol. Take plain old aspirin or ibuprophen instead!
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Replied By Derek (San Francisco, CA) on 12/18/2008

Acetaminophen can cause severe liver damage in combination with alcohol, and should NOT be taken until all of the alcohol is out of your system! This is written on the bottle. The same warning is found on Ibuprofen products.
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Replied By Kira (Saratoga, NY) on 12/23/2008

I don't drink a lot but once in awhile I binge drink. I make sure prior to drinking to hydrate with filtered water all day long and maybe a Vitamin C or multi. It also helps to drink top shelf vs/ well (cheaper liquor can have more additives/preservatives). Also when you're drinking, get a glass of water to drink too. I could have three to four Long Island Iced Teas (over 4-6 hours) after not drinking for many months and wake up without a hangover in my 30s.

Honestly, I don't recommend binge drinking but I get shy when I go out and sometimes it happens. I know myself and make sure I drink the water. I think much of a hangover comes from dehydration and not listening to the body. I haven't got sick in half-a-dozen years. My b/f drinks regularly and still get sicks, because he doesn't listen to the body when it says stop or don't eat greasy food on top of all the drinking.

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Replied By Kreyelle (Lafayette, Co, U.s,a,) on 09/15/2010

Yes please do not take acetaminophen if you drink alchohol, especially if you are a heavy or binge drinker. Not only does it damage your liver but my daughter's friend's Mother, who was a binge drinker died from her organs shutting down. And it was because she took, that night acetaminophen. Confirmed by the doctors. I am sure this is a severe case but why take the chance.
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Replied By Tom (Regina, Sk) on 09/15/2010

There are actually pre-mixed supplement capsules on the market that have proved for thirty years to prevent hangovers by supplying various antioxidants and liver-protective ingredients. They are even named as some kind of hangover preventative or anti-alcohol antioxidant blend. The main key ingredients are always Vitamins C, E, and the amino acid "NAC", or n-acetyl cysteine. Then there are up to a dozen others in the mix. NAC is readily recognizable as the one key nutrient used by hospitals to save people admitted from kidney and liver failure from overdose of acetaminophen! Some of those others are chlorophyllin, selenium, zinc, copper, barley grass, thiamin, etc. Here is a quote from one page of a long article explaining why booze can hurt so badly after over-consumption! :

Reactive oxygen species (ROS) have been associated with acute ethanol-induced liver damage. A study published in the journal Artery confirmed a specific toxic metabolite of alcohol (acetaldehyde) and identified an antidote (N-acetyl-cysteine): "All known pathways of ethanol metabolism result in the production of acetaldehyde, a highly reactive compound. N-acetyl-cysteine (NAC), an analogue of the dietary amino acid cysteine, binds acetaldehyde, thus preventing its damaging effect on physiological proteins. "45 NAC is a glutathione precursor and direct antioxidant. Pretreatment with or co-administration of NAC helps to inhibit acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress

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