I have had GERD (reflux disease) for six years now. I started taking ranitidine and then quickly worked my way up to nexium from 20mg a day to 40mg a day. Even on 40mg a day, I still had signs of persistent GERD in the form of chest pain. I read about MANGOSTEEN, a natural fruit juice that is becoming more popular and decided to try it for its general health purposes. I did not expect that it would keep me off of my nexium!!! I take 2 -3 1 oz shot glass size drinks a day and I have not taken my nexium since October...it is now February! If I miss a day, I do feel it. But I feel great not taking the prescribed medication.