Arthritis in my hands and knuckles has been cured with tweezers and hundreds of days picking and soaking. It was so bad my thumb wouldn't even open. I had been a machinist, welder, gardener and hiker. Each of those pass-times had added foreign objects into my skin.
Burns, cuts, grinding sparks, splinters, thorns and thistles were all complicit in my hand injuries. My hands were very obviously tough, calloused and curled into claws. As a machinist I was proud of my tough man hands until they lost their ability to serve me.
Last year I decided to try to save them and have been soaking in vinegar water, Epsom salts and tweezing away the callouses. This revealed things underneath that could come out.
A year later and a thousand hours of soaking/tweezing the end is in sight. My thumb moves and the fingers are well on their way to being teenagers again.
So there is hope for others that feel they can profit from this path.