Melatonin's Topical Benefits: 40 Ways It Soothes Pain

This new study suggests melatonin lotion is effective in treating mild to moderate psoriasis:

https://onlinelibrary.wiley.com/doi/10.1111/srt.13689

Here is a relevant study quote :

' Also a significant decrease of 35% (mean (SD) of 2.67 (0.98) to 1.74 (1.12)) and 51% (mean (SD) of 2.67 (0.98) to 1.31 (1.13)) in PASI score, and 40% (mean (SD) of 5.00 (1.58) to 3.00 (1.76))and 61% (mean (SD) of 5.00 (1.58) to 1.92 (1.71)) in DSS score on days 30 and 60 with melatonin cream, 5% w/w (P < 0.001) compared with baseline were observed, respectively. In each of the melatonin or rosuvastatin groups, DLQI improved significantly on days 30 (P < 0.0001) and 60 (P < 0.001) while the changes in the control group were not significant. '

I had already reported that it was synergistic with certain psoriasis medications in the list of 40 items (#34) and helped eczema of the scalp (#6) while other studies suggest it can be useful for atopic dermatitis and other skin conditions, as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967801/

Here is a relevant quote :

' It has cytoprotective, immunomodulatory, and anti-apoptotic effects. Melatonin is also one of the most powerful natural antioxidants, directly acting on free radicals and the intracellular antioxidant enzyme system. Furthermore, it participates in antitumor activity, hypopigmentation processes in hyperpigmentary disorders, anti-inflammatory, and immunomodulating activity in inflammatory dermatoses, maintaining the integrity of the epidermal barrier and thermoregulation of the body. Due predominantly to its positive influence on sleep, melatonin can be used in the treatment of sleep disturbances for those with chronic allergic diseases accompanied by intensive itching (such as atopic dermatitis and chronic spontaneous urticaria). According to the literature data, there are also many proven uses for melatonin in photoprotection and skin aging (due to melatonin's antioxidant effects and role in preventing damage due to DNA repair mechanisms), hyperpigmentary disorders (e.g., melasma) and scalp diseases (such as androgenic alopecia and telogen effluvium). '

It seems that we are just scratching the surface of what melatonin lotion can do!

Art

Hi Mary P,

So the one quarter teaspoon is all melatonin and it equals approximately 750 mg of melatonin. You have to consider that melatonin capsules contain a significant amount of fillers so it will take much more than a 1/4 teaspoon of these capsules to get to 750 mg of actual melatonin. It will take the amount of capsules that it takes to equal 750 mg of melatonin. So if you have 10 mg capsules, it will take approximately 75 of these 10 mg capsules to get to that 750 mg area and you can see that 75 capsules is going to be way more than a quarter teaspoon.

There will also be a problem with the solubility of the fillers which may not dissolve in gin and will make the lotion feel gritty. Another potential problem is that some of the fillers may dissolve in the gin, but that may preclude the melatonin from fully dissolving in the gin in which case you will essentially have a diluted mix which may not be effective at all.

I recommended melatonin powder because that is what my friends used and found effective. Since those first three friends reported their results, many other friends and acquaintances have also reported significant benefits from using that same mix.

I highly recommend following what they did in order to make an effective melatonin lotion.

A few friends have reported that mixing all three ingredients together at once by mistake, produced a lotion that gave little to no pain relief. You have to thoroughly dissolve the melatonin in the gin first and then add the lotion to that mix, otherwise the lotion will offer little to no benefit.

Art

Hi Art! I have melatonin caps… can I open them and prepare this recipe? We only need a 1/4 teaspoon.