Pet Medication Side Effects & Drug Detox

Last Modified on Nov 02, 2014

Earth Clinic has already received extensive reports on the ailments and side effects caused by medicines prescribed for our pets by well-meaning veterinarians, and we're concerned. Please let us know about any side effects you have witnessed after your vet administered a new prescription or medication. We'd like to know the breed of your pet and also which medication/prescription he or she received. The more information you can give, the more clearly we can make conclusions about which medical treatments are causing side effects in our dogs, cats, and other pets and how best to treat them.

Please note, if your pet has experienced side effects from a vaccination, please read our extensive pet vaccination side effects page.

Home Remedies for Pets Suffering Medication Side Effects

If your dog, cat, or other pet is experiencing ill health or various side effects from a veterinary medication, you may want to consider activated charcoal, bentonite clay, or homeopathic nosodes for dogs to counteract the effects of the drug.

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User Reviews

Allergy Shots   0  0   

Posted by Pamela (Ada, Oklahoma) on 06/01/2009

[SIDE EFFECTS]  My bull terrier has received allergy shots in the past. The past week I took her for her regular shot, but they gave her a dose for a 61 to 80 lb dog. She weighs between 60 and 63 lbs. I had noticed side effects before, but not this drastically. She has been having panting episodes, especially at night. She seems more hyper and cannot get enough food.

I have been monitoring her intake as her stomach has been swollen since the shots. She has also had a very loose stool since the shot. I have given her 2 kinds of medicines for bacteria in the stomach since this happened.

I am really worried about her since I read the other readers comments about the side effects of allergy shots. I will NEVER take her to this vet again. I think they over dosed her. I am going to find another vet probably in another state as the vets here in Oklahoma seem to have no clue what they are doing. I had a 2 year old bull terrier die in November because he started having seziures. The vets here had no idea why...I just don't think these people are interested in anything but getting your money. No more allergy shots for my dog. I will find an alternative solution.

Posted by Wendy
Vancouver, Washington
Many thanks to all of you warning about the allergy shots. I have a 20 lb, 2 yr old Jack Russell terrier who has bad allergies (very loud snoring, and probable sleep apnea). He has also had three seizures since I rescued him last Feb. He was severely physically abused and neglected, but otherwise I have no medical history on him. I have had no past experience with terriers, or any other small/med sized breeds, nor these two medical conditions. But I will definitely avoid any shots. Any further posts to help me help my dog is greatly appreciated! And please feel free to email me:

Antibiotics   0  0   

Posted by Tome (Hendersonville, Nc) on 04/02/2011

[WARNING!]  I do not know whether the bacteria that is causing havoc among people taking antibiotics is a problem for our animals but just in case, I would think it wise to include some acidophilus in your animal's diet while he or she is on the antibiotics. Once a person is suffering from c. Diff, it is very, very difficult to cure. The cramps alone will bring a strong man to his knees and our animals will not be able to tell us about the cramps. Also, until the c. diff is under control with acidophilus, one cannot eat even a bite of banana (in my case, at least) without bringing on the cramping.

Posted by Liz
Kenmore, New York
[SIDE EFFECTS]   My 14 yr old male Norwegian Forest cat was given antibiotics to treat dental problems he was having. I was in bad shape financially, and could not pay the full amount of all the tests and cleaning, (because the vet, like every other vet, refuses to do payment plans) so the vet put him on a 2 dose a day antibiotic. He doesn't weigh too much anymore because of his age, so I was very surprised when they told me the dose was 1mL, which was the entire tube dropper. Just seemed like way to much. Especially when they told me that he developed a heart murmur.

So I gave it to him and within the first 2 days, he started vomiting up this white bubbly phlegm all the time and had diarhrea very bad. I had called the vet, and they said it was "normal" and to not worry about it and it would go away within a few days.

The next few days were spent with him hiding constantly (which he only does when he's hurt or sick - which is very rare) and his appetite went way down and he stopped going to the bathroom all together.

Within the end of that week of him being on it, he had a stroke when I was in the middle of brushing his hair. I immediately stopped giving him the antibiotics and hoped he would recover from having the stroke because by the next day he was walking around and eating again.

But he hasn't. He's gotten worse and he's still vomiting up that white stuff. And now he refuses to eat, drink and still hasn't gone to the bathroom. And to make matters worse, I've called every vet in the city and no one takes payment plans so I can't even treat him. All they keep telling me is that he'll need a whole bunch of tests and that it's going to cost a lot of money which is due at the end of the visit, and they won't even see him unless I can pay the entire bill. Talk about being in it for the animals!

He was fine before he got put on this stuff, and now I have to watch him slowly die because of it. He was the most loveable cat and would cuddle, bring me socks, play and chase our other 2 cats around the house. Now all he does is sit in the tub or hide under the bed and we've been forced to feed him using a syringe. He was the best cat ever with the most unique personality and now I'm forced with the decision to euthenize him or not, which is the hardest decision I've ever had to make. He was my little boy and I love him to death and it's their fault that this is happening to him!

Posted by Timh
Louisville, Usa
1047 Posts
Liz, I am terribly sorry for this incident (accident). The Hippocratic oath has been broken again. I also hope your kitty is still alive as of this writing. If I may suggest a couple of things which might help. First, I am a big advocate of magnet therapy as it helps sooo many conditions. If you have a refrigerator magnet rub your kitty with the side that sticks to metal surfaces. Do this for several hrs if possible on a daily basis. If possible buy him a magnet pet pad to sleep on. For internal cleaning, add one drop of H2O2 3% (Hydrogen Peroxide) to his water dropper. Slowly increase by one drop until he is back to normal. Hope this isn't too late.
Posted by Ali
Dothan, U.s.
Side effects, Dear Liz , I just found this site, so I know this comment is late in coming. But I still wanted to express my deepest thoughts to you. I hope so much your baby made it. I'm going through a serious problem with my cat too. She has been sick for so very long and is on antibiotics again, and the Vets have drained my senior income and put me in debt that will take the rest of my life to get out of, if I live that long. And yes, I'am very, very bitter about it too, because they still have not found any solution to help her.

With the office visits costing so much with every trip ( $38.00 To $52.00 a visit) I could never save up enough money to pay for the treatments they kept needing. (Seniors have a hard time trying to just pay for their pets food. I do without many times so she can eat. ) and, I feel I have to keep trying to help her and not give up on her she is my Love, a Big part of my life. Now with over $7,800 in credit card bills and watching her die, I'm beyond depressed. I can't find the strength to put her to sleep. The Saddest part about it too, is, the disrespect I felt from the office staff because I would ask about the cost of each test and why it was needed, and sometimes the test were just crazy to do. And always, always in a rush to get you out, and won't talk to you. I have never felt so lost and low in being a human being as I did in my Vets office. They all acted so insensitive to the deep love I had for my cat and made me feel like I was cheap and just a crazy cat person and wanted service for nothing. I feel I will Never try to own another pet and Not because I don't think we need to help our animals , but, because I 'am going to Refuse to EVER support another Vet in my life time. I have Learned a thing or to about them through all of this. Most of them have a need to take a serious look at their morals, and learn Money isn't Everything, and realize humans have brought on this over population of animals and put their life in harms way and we owe it to them to help them. You would think a Vet would be a lot more caring, but, they are not, it's a very sad state for those of us that do care, but, have to suffer so much trying to help them. I have Lost a Big part of myself because of my resentment about This So Called Profession of doing it for the animals. A loving Pet owner deserves more respect because of their Love for their pets. So many pets are abused so very bad.

Posted by Om
Hope, Canada, Bc
39 Posts
I completly sympatise with the agony and sorrow these vets have caused to you and the kitty. I have had a cat hospice since in my early fifties and now I am seventy-seven years old with some dogs/cats remaining. Vets have killed several of these cats that should have been treated with love, not greed. I have had to experience cats dying of broken heart, abandonment and othere factors. This has broken my life to some extent. Even now I am mistreated by city hall even though everything is in order with numerous letters of support. Antibiotica are given for everything and the result is often a cat literally withering away. I give diluted buttermilk or yoghourt for a long time, even baby probiotics and have put some now on a famous tea that has the name of the nurse in reverse that cured thousands of sick people here in Canada in the past. Now I give natural Ayurvedic and western remedies that are for people which are supporting and healing.

I found vets putting down pets that should have been left to die naturally with the support of the owner as I have done. I have only one hope that in the near future there will come a completely different healing system, not a sickness system based on dollars. These vets are heartless, cruel and avaricious. I once volunteered for a vet only to realize that these people have sold themselves out to a life of money raking, forgetting their purpose in life.

My life was full of pain and because of the agony I had to witness without hardly any support of two-legged ones. The love I have received was beyond words and I know they are far more aware than people have them be. Even now I am ostracised and driven out of a international spiritual community because I am considered unclean because of my life with cats and dogs in need. God bless you all animal guardians and look forward to times when this cruel and spiritless system will disappear. Om

Azoxystrobin   0  0   

Posted by Ney (San Cristobal, S. C., Dominican Republic) on 08/21/2010

[WARNING!]  Warning! Amistar 50 WG is the name of a commercial product whose active ingredient is azoxystrobin. It is used in agriculture against certain types of fungus. I used it with my dog trying cancer. Nevertheless, after the treatment finished, my dog developed a kidney infection. I cannot, positively, say the azoxystrobin causes the infection, but, just be careful. God bless you...

Bentonite Clay to Counteract   1  0   

Posted by Fiona (London, England) on 06/24/2011

[YEA]  My cat was in a bad way from being overdosed at the vets with drugs. He developed diahrroea with blood in it and after the vets medicine for the diahrroea failed it occured to me to try some Bentonite drink. He took this without resisitance (unlike the vets medicine which we struggled to get into him) and after eating about a teaspoon worth of thick Bentonite mixture (hydrated of course... DO NOT GIVE DRY BENTONITE)he was back to normal the next day thank God

Research the healing effects of edible clay.... It's marvellous stuff. I always have some ready to go (as you must have allowed the Bentonite clay to absorb the water for a minimum of 20 minutes)

All the best,


Clavamox and Doxycycline   0  0   

Posted by Sandyb (Shamrock, Tx) on 04/08/2012

[SIDE EFFECTS]  My 7 yr old Pembroke Corgi has a history of allergies, bladder stones, and recently, contracted a Staph infection. Culture taken from inside the nose as she was having stuffed nose, crusty skin on outside of nose. Found one sore, very small on right flank. She was not herself, took her to vet, she put her on Clavamox for seven days. She appeared to worsen, took her back, changed her to Baytril and added Doxycycline. Got culture back on nose swab and put her back on Clavamox and to continue with bacterial Doxycycline. She continued to worsen, no appetite, vomiting, fever, white count had not changed, losing weight. Took her back 3/23 and she was given Covenia injection to treat the Staph and was given another round of Doxycycline to take with Covenia. She has continued to decline, no appetite, did not have fever this past Friday when took her back as she suggested she get a B-12 shot to give her some energy. On exam her left eye was completely dialated and did not grow smaller when flashlight instrument went over eye. Also the vomiting still happening about every other day to two days. She said to use Famotidine acid reducer with food to keep acidity down. I had noticed late Friday night her problem with swallowing and she would try to eat some cooked chicken but would quit after a few bites. It was apparent her throat hurt and she would cough and spit up clear slime. After a thorough reading about Doxycycline side effects I believe she now has a possible throat lesion from this med. Also, on the Covenia site it states that Doxycycline: "CONVENIA has been shown in an experimental in vitro system to result in an increase in free concentrations of carprofen, furosemide, doxycycline, and ketoconazole. Concurrent use of these or other drugs that have a high degree of protein-binding (e.g. NSAIDs, propofol, cardiac, anticonvulsant, and behavioral medications) may compete with cefovecin-binding and cause adverse reactions."

I stopped the Doxycycline Friday after she had her am pill. I am waiting to see tomorrow if she is improved at all. This morning she coughed up blood streaked slime.

Please respond to my inquiry as soon as possible. She now only takes chicken broth in a baby med dropper, no solid food at all because of apparent throat pain.

Posted by Sandyb
Shamrock, Tx
I want to amend the above post as my Corgi, Buffy did not have a reaction to the Doxycycline but last week was diagnosed with Dysautonomia, a horrid disease that strikes dogs, cats, horses, rabbits, and I read a Llama got the disease. There is no known cause, treatment is just to keep them comfortable and the mortality rate is 90% in dogs, 70% in cats. This disease attacks the neurons in the ganglia that controls the involuntary functions like eye dilation, blink function, respiratory, coronary, digestive functions. There is no cure at this time and our beloved companions either die of aspiration pneumonia or are euthanized due to poor quality of life. Our Buffy is no longer with us and we miss her terribly. This disease started in Europe in the 1900's and first canine was diagnosed in Missouri in the late 1980's. Missouri and Kansas are most hard hit with the disease but other states have reported it. Rural dogs close to pasture land and ponds are at risk vs city dwelling dogs. Research studies show some information that it could be due to pesticides and/or herbicides. I just wanted to correct the prior information I gave in my post so people will become aware of this disease that apparently increasing in number although still considered a rare disease. Thank you.
Posted by Jeanir
Pittsburgh, Pa
I know humans benefit from cayenne pepper when overdoses or accumulation of pesticides is the problem. I knew someone that was almost completely paralized and came back to normal, by using cayenne pepper everyday, he was a farmer. He still uses it everyday because he thinks it was his life saver.

Cortisone   0  0   

Posted by Patrice (Melbourne, Australia) on 01/21/2013

[SIDE EFFECTS]  I took my 14yr Border Collie to the Vet for a back problem requiring acupuncture, whilst there the Vet convinced me to try a short five day course of cortisone for her. Within a couple of days she was panting hard and had excessive thirst and hunger, followed by a complete collapse. The Vet diagnosed it as Distibula (an inner ear problem) but my brilliant Natural Therapist, Kinesiologist, Energy worker said it was a stroke, neurological (not an inner ear problem) caused by the cortisone, which had blocked Sally's immune system from working correctly when she had eaten some broccoli that wasn't organic and had been sprayed with pesticides. Her system couldn't cope.

Thanks to the Natural Therapist and Homeopathy Sally made a pretty good recovery.

That's what Cortisone does: blocks one's own immune response to dis-eases, which can then run rampant. and is like fertilizer to cancer.

Posted by Ingrid
Daytona Beach, Florida
[SIDE EFFECTS]   10 y/o chihuahua with CHF. Vet gave cortisone injection, dog went lethargic. She walked like a drunk and kept falling down.

297 sugar, liver GGT 44, BUN 144, I brought her home with IV electrolytes and insulin. I don't know how she made it through the night. NEVER give your pet a cortisone shot. They stopped giving them to COPD patients as it compromises the immune system. I will let you know if she makes it a week.

Posted by Nancy (Sioux Citiy, Iowa) on 04/09/2009

[SIDE EFFECTS]  My young cat Daphne about 1 yr old in 8/08 injured her paw. The veterinarian gave her two cortisone injections a week or two apart. Her injured paw is fine but she now has some sort of skin infection that moves around her jaw, chin, neck, shoulder area that presents itself in thickened skin and scabbiness. It seems to be in one area, then moves from one area to another. The skin where the infection once was will seem perfectly normal for awhile, then this thickening comes back again. She appears healthy otherwise, but she has had this skin problem for well over half a year now. Also she wore a plastic Elizabethan collar for 1 1/2 weeks while her paw healed, due to her excessive licking of her paw. I'm not sure which contributed more to her skin problem, the cortisone or the Elizabethan collar. Before she hurt her paw she was perfect in every way.

Posted by Brenda
San Antonio, Texas
11 Posts
I have found that for a small dog 1 teaspoon of whole organic aloe vera daily works wonders for dogs or cats with allergys of any kind. Please check the animals food for chemicals. What is in the treets you give them. Brenda

Posted by OTH (Atlanta, GA) on 11/20/2008

[SIDE EFFECTS]  My dog was scratching a lot (been a life long scratcher) but otherwise perfectly healthy so I bought him in to the vet one day when I had to bring in my other dog. The vet gave him a cortisone shot and said he may eat, drink and pee a lot. He was fine for the first 24 hours but then had a night of severe vomitting (9 plus times including blood) and was left lying and shaking in pain. He has now been at the vet for 24 hours on an IV and is in the same condition and still won't eat. No one at the vet warned me about these kinds of side effects and we don't know yet what will happen. Wish us luck.

Posted by Amy (Glendale, Arizona) on 09/29/2008

[DEATH REPORTED]  I took my 14 year old cat to the vet because she was limping. The Dr. determined it was her elbow, and gave her a shot of cortisone. My cat stopped eating, and 48 hours later I had to put her down. The cortisone may have brought to light an underlying problem, renal failure. I know she would have shown symptoms eventually, it all just happened so fast.

Posted by Rick (Huntington Beach, Ca ) on 06/13/2008

[DEATH REPORTED]  Cortizone shot: I had 12 year old Lab in healthy condition.Within two weeks he begin vomiting became lethargic. Took him to the vet died two days later.dont know if the cortizone shot weakened his resistance or not. Vet said he died of a bacteria that went toxic.

Posted by Romina
Los Angeles, Ca
I didn't know of any of these side effects when my dog got the shot. He is 3 years old now and has about 4 of these shots. He has very bad allergies and itching all his life but the treatment for that is too expensive for me. The shots seemed to work fine with him for about 2 months but the itching would return. He's never seemed to have any of the side effects listed only that he would drink more than the normal amount of water. Thank you all for your posts I will be sure to NEVER get him that shot again. Are there any ideas of anything else to do to stop the itching??
Posted by Mountainlady
Bakersfield, Ca
My black lab has had skin itching most of his 12 years. After many useless trips to the vet, my feed supplier suggested changing his food. We now feed all natural products with no chicken or beef products or by products. He cannot tolerate the grains or glutins in anything. He is now fed duck and potato canned food and a glutin, meat and grain free dry food for several years. His skin condition has improved greatly and the itching has stopped. Most of the time, I have found the allergies are caused by food. The vet didn't bother to tell us that and would rather medicate than suggest a change in the diet. Unless of course they are able to sell you the food. Don't fall for that either. We also found that he is allergic to a lot of stuff in treats. When he starts itching again, we stop what ever is new to his diet. Now he gets dry white bread toast pieces for a cookie treat and he has no problem with that. They are crunchie and he loves them.
Posted by Max
Monterey, Ca
[SIDE EFFECTS]   hello.. We just took our 6 year old beagle to the vet because his ears were itchy. Vet said ears were just red inside and gave him a coritsone shot and some ear drops it has been 4 days and he has drank a ton of water, seems uncomfortable and peeing a lot. Vet said he would drink and pee a lot. After reading everyones comments I will never go the cortisone route again. thank you all for your comments even though many of them are heart breaking..

Depo-Medrol   0  0   

Posted by Redragtop (Pocomoke City, Maryland) on 06/30/2014

[DEATH REPORTED]  My beloved 10 year old Siamese cat was in distress from fleas, so I called our local vet for some help. Our Vet was not in, but his nice young associate helped us. He agreed that my baby showed signs of an allergy to fleas, and gave him two Depo-Medrol shots to make him "feel better in a couple of days", and sold me a topical flea medication for "instant relief". This was on Friday afternoon.

On Saturday, my cat stuck to me like glue. I couldn't leave his sight. He wouldn't eat, but I could get him to drink water. At bedtime, I put him in my bed. After several hours, my baby woke me up with a terrible cry, and started with a seizure. He had seizures all night long, and passed at 4:45 Sunday morning.

Now, I find out that Depo can cause kidney failure .... the vet didn't warn me ...... it was supposed to make him feel better .....

Posted by Diamond
Ma, US
66 Posts
To Redragtop, owner; I am so sorry for your loss, I know how it feels to lose your loving pets. I hope in time your sorrow and pain will go away. I guess like most of us learn the hard way, there are no real answers, right or wrong, but we do learn from mistakes made. She is still with you in spirit and will let you know he is still there with you. God Bless.
Posted by Theresa
Mpls., Mn
542 Posts
Hey Redragtop!

I am very sorry for your loss.

Please report the death of your dear Siamese to your vet. At the very least, blood work should have been performed prior to giving your cat this injection to ensure your cat's organs were able to process this synthetic steroid properly.

What a senseless loss - I am so sorry.


Deramaxx   0  0   

Posted by Jim (Renovo, Pa) on 04/24/2011


his weight is 75 pds and was given 37 mg per day.

the vet felt it was not the DERAMAXX . He was fine until I gave him this pill. day after I stopped it he is back to about 80% and is peeing and walking .

pupils have returned to normal and he is loving dog he has always been.

folks STAY AWAY FROM DERAMAXX, I know it works on some dogs but I believe if I would not have stopped it after 4th day my lab would be dead. Not blaming the vet but it is not SAFE for every dog. vets feel its like aspirin, ITS NOT AND COULD KILL YOUR DOG.

Posted by Lorant
Tryon Nc
2 Posts
Would not be surprised at this at all.... The Dermaxx is a recycled drug that the FDA banned for humans, you may remember.... It is VIOXX!! Killed a lot of people and many others nearly died of side effects. The Big Pharma companies do this quite often with defective human drugs, just shift them over for use at the vet's office. Most people do not know this! No money lost this way... Sad, huh??

Effexor   0  0   

Posted by Cheyenne (Lakewood, Colorado) on 07/21/2011

I had a cat who died very suddenly at 4 1/2 years of age, he was fine the evening before, dead the next morning. I had a room mate at that time who was on 475 mg effexor and I have seen her drop pills. Would effexor have been deadly if my cat had swallowed one pill? What other causes could there have been for him who was healthy to all of a sudden die?

Flea/Tick/Heartworm Medications   0  0   

Posted by Katie (Albany, Ny) on 09/04/2011

[SIDE EFFECTS]  Anybody's dogs have reactions to Vectra 3D for fleas and ticks. My dog is all scabby and has blisters where I put it on his back, the vet said it was his allergys, BUT it's only where I put the stuff.. Any response will help.. TY

Posted by Lindak220
Hoffman Estates, Il, Usa
I know your post is from Sept 2011; however, I found a spot on WebMD for pets after experiencing a terrible reaction with my 3 yr old shih tzu. I have since bathed her and will be starting her on a ground turkey / rice diet. She is on day 2 of diarreah and has experienced hyper activity as well as increased heartbeat. I read in the email thread that between small dogs and cream colored dogs (my dog fits both criteria) this flea / tick med should not be used. I also read on a 50/50 combo of ACV/Water to help prevent ticks; I am going to be looking in to that closer as it is natural.

Posted by Skeeterone (Pegram, Usa) on 08/28/2011

Read lots of posts about pet's vaccines, diet, etc.

Does anyone have any comments on Heartguard or Tri-Heart Heartworm meds when given to herd dogs?

I do warn that even a dog like mine, a Fila Braziliero Mastiff, that has some herd dog in her breeding background should not be given Heartworm meds. I have never given the meds before, I read extensively. I had never given the heartworm meds before because it is so toxic. But with weather changing all over the country I decided the chance of heartworms was becoming so prevalant that I would go ahead and go against my true feelings. I treat my lawn, my dogs (also toxic) for fleas, no stagnant water, etc.

My Fila puppy was 3 mos old when I first gave her the meds. She has been itching and biting herself intensely ever since, I tried everything, vet said probably an allergy but did not venture a guess as to any possibility except diet or flea control. I have tried everything, from hydrocodone spray, to creams, a weak clorex bath, apple cider vinegar, changing her diet, etc. Never used too much flea control dip.

I discontinued the heartworm meds, just a week ago. She seems some better for the first time in almost 4 mos. She has always had a beautiful coat, and seemed to have healthy skin, etc. Now there is some breaking out on her inter legs, not on her body which is the main area she scratches and bites on. Maybe the the breakout is kinda like measles, or chicken pox in humans. Maybe the allergy has moved to the skins service and is going to go away.

I also have given her vitamin C in the form of calcium absorbate because she was a winter pup and to help her immune system and MSM a natural sulfur that I gave her for a birth defect in her spine. I discontinued both for now.

I just wondered if anyone has had any bad side-effects from giving their pet heartworm meds.

I know there are much worst side effects and damage that heartworm meds can do than just itching. I also have found thru reading that its easier to get rid of heartworms, than to treat the side effects that sometime never go away. I hope my baby girl, Jazzi, is not one of the unlucky ones due to my error. After reading the posts in this website, I'm almost afraid to give her a rabies shot.

Where is all of this going to stop. The food that we and our pets buy is unhealthy for us, and meds are the same and getting worse or else all the info we have now is just now coming to light for people like me. It's all about greed as far as the profitable situation that selling all these poision products are putting big companies that we once trusted....... We can no longer know anything is safe.... Not for sure.

Unless we grow our own garden and slaughter our own animals for food for us and our beloved pets. Even then the enviroment is questionable also.

Would hope to read someone's experience with heartworm meds. Or learn any info that I might not have read or heard about. There seems to be there's nothing that's safe. Years ago there was worry of plagues, now we have to worry about vaccines, meds, and most everything that was put into place originally for eraticating disease. Now only profit seems to be the issue with big business for man and his best friend.

Thanks for reading, May God Bless all the humans and pets adversely affected by the state of our world.


Posted by Gregory
Dfw, Texas
We have a boxer mastiff and a greyhound. We live in the southern part of the US and there are many mosquitoes during damp wet warm weather. Both of our dogs have been on the Tri Flex - heartworm, tick, flea combo.

My greyhound showed a swollen ridge around the back of his neck. Then on this seaon the first dose he got a large black spot on his tounge, he was lethargic and he kept contstanly looking back at his hind quarter. A week or two later large black spots formed on both upper side of his hind quarter. Afraid this might be kidney, adrenals, or liver, I did not give him the next months dose and he has cleared up nicely.

Greyhound got his energy back with normal alertness. Everytime he goes out I spray him with full strength Listerine which he doesnt seem to mind. And I give him herbal wormwood just in case. I am praying that he test out negative again in six months. The boxer mastiff just seems agitated all of the time since he went on Tri Flex and both had started bad dreams after they went on it. Its a tough call.

Posted by Melanie
Tennessee, US
I have a 9 month old American Bully pitbull puppy. He got his first 6 month tri heart heartworm shot today and he is really lethargic. He is normally very active during the evenings. But all he is doing is sleeping. He stares into space and freaks out over something that isn't there. Is he going to be ok? He was on the tri heart pill and he was fine. But now im worried about the shot. I got it for him bc I am moving and I wouldn't have the money to get he pill for a month or two. Is lethargy a common side effect from this or is it something I should be worried about?
Posted by Theresa
Mpls., Mn
542 Posts
Hey Melanie!

You should contact your veterinarian immediately and report the side effects you are seeing.

I think you have your meds mixed up. Tri-heart is an oral ivermectin/pyrantel combo drug that is given monthly to prevent heartworm as well as other common worms in the GI tract such as roundworms. The only injectable heartworm medication is Proheart 6 - lasts for 6 months, and the working drug for that product is moxidectin. The side effects you are seeing - lethargy - is associated with moxidectin. This drug was pulled from the market because it caused many adverse reactions and deaths among pets that administered this drug. The manufacturer made some changes to make it safe[er], and it was then re-released, however the product website states that if you notice any side effects to contact your veterinarian immediately as if may be a life threatening situation:

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